碱化血液灌流治疗有机磷中毒的效果观察

目的比较碱化血液灌流与常规血液灌流治疗重度有机磷中毒的效果。方法选取重度有机磷中毒患者60例，随机分为两组，每组30例，常规组采用血液灌流辅助治疗，实验组采用碱化血液＋血液灌流辅助治疗，比较两组胆碱酯酶（CHE）活性恢复时间、阿托品应用总量、住院时间、死亡率等。结果与常规组比较，实验组患者血清CHE活性恢复时间、住院时间明显缩短（P〈0．05），阿托品应用总量明显减少（P〈0．05），死亡率明显降低（P〈0．05）。结论碱化血液灌流治疗有机磷中毒，效果较好，值得临床应用。

The effect of alkalization of the blood treatment combined with hemoperfusion in the patients with organophosphorus poisoning

Objective To observe the clinical effect of conventional hemoperfusion and alkalization hemoperfusion in treatment of organophosphorus poisoning. Methods 60 cases of severe organophosphate poisoning patients were ran- domly divided into two groups with 30 cases in each group, the patients in experimental group were treated with blood alkalization and hemoperfusion treatment, the patients in conventional group were given hemoperfusion treatment. Then the serum cholinesterase （CHE） activity recovery time, hospital stay, and the mortality rate of two groups were com- pared. Results Compared with conventional group, the serum CHE activity recovery time, hospital stay were signifi- cantly shorter （P〈0.05）, dosage of atropine was significantly reduced （P〈0.05）,the mortality rate was lower （P〈0.05）. Conclusion The effect of blood alkalization combined with hemoperfusion in the patients with organophosphorus poisoning were satisfactory, and it is worthy of clinical application.