硫普罗宁治疗抗结核药物所致肝损害的效果观察

目的探讨硫普罗宁治疗抗结核药物所致肝损害的效果。方法选取本院收治的抗结核药物性肝损害患者130例，随机分为两组，分别行常规治疗与硫普罗宁注射液治疗，对比两组临床效果与安全性。结果观察组患者治愈率与总有效率高于对照组，肝功能检测显示丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBiL）、谷氨酰转肽酶（γ-GT）、AST／ALT均显著优于对照组，两组患者均无严重不良反应发生。结论硫普罗宁治疗抗结核药物性肝损害效果显著，能有效改善肝功能，减轻临床症状，且安全性较好，适合临床推广。

Observation of the curative effect on tiopronin in treatment of liver injury induced by anti-tuberculosis drugs

Objective To investigate the clinical effect of tiopronin in treatment of liver injury induced by anti-tuber- culosis drugs. Methods 130 patients with liver injury induced by an-tituberculosis drugs in our hospital were selected, they were randomly divided into two groups, and respectively given conventional therapy and tiopronin injection treat- ment, the clinical efficacy and safety of the two groups were compared. Results The cure rate and total effective rate of observation group were higher than that of the control group, liver function tests showed ALT, AST, TBiL, γ -GT, AST/ALT were significantly better than the control group, and there was no serious adverse reactions in two groups. Conclusion Tiopronin has significant efficacy in the treatment of anti-tuberculosis drug-induced liver injury, and can improve liver function, relieve clinical symptoms, and it has better security, is worthy of application