变应性鼻炎严重度与胸腺调节趋化因子及嗜酸粒细胞趋化因子-2的关系

目的研究变应性鼻炎严重度与胸腺调节趋化因子（TARC）及嗜酸粒细胞趋化因子-2（Eotaxin-2）的关系，总结这两个趋化因子在变应性鼻炎发病机制中所起到的诱因性作用及临床意义。方法采用酶联免疫吸附实验法对33例无变应性鼻炎患者（对照组）及104例变应性鼻炎患者（临床组，其中轻度鼻炎患者52例为临床甲组，中重度鼻炎患者52例为临床乙组）进行TARC及Eotaxin-2的光密度值检测，并进行综合对比。结果临床组血清TARC、Eotaxin-2水平较对照组高，差异有统计学意义（P〈0．05），两组数据数据呈正相关（r=0．970，P〈0．01）。临床甲组与临床乙组TARC及Eotaxin-2的水平差异无统计学意义（P〉0．05）。结论Th2型细胞主导的炎性反应最终引发变应性鼻炎，但变应性鼻炎患者其体内炎性因子水平与变应性鼻炎的严重程度无显著关联。

Relationship among severity of allergic rhinitis,thymus and activation regulated chemokine,and eosinophil chemotactic factor-2

Objective To study the relationship among severity of allergic rhinitis,thymus and activation regulated chemokine （TARC）,and eosinophil chemotactic factor-2 （Eotaxin-2） and summarize the induced role and clinical sig- nificance of these two chemokines in the pathogenesis of allergic rhinitis.Methods 104 cases of patients with allergic rhinitis （clinical group,52 cases of patients with mild rhinitis were as clinical group A,52 cases of patients with moder- ate to severe rhinitis were clinical group B） and 33 healthy people （control group） were tested for optical density of TARC and Eotaxin-2 by enzyme-linked immunosorbent assay and the outcomes were compared.Results The level of TARC and Eotaxin-2 in the clinical group was remarkably higher than that in the control group （P〈0.05）,the results displayed positive correlation （r=0.970,P〈0.01）.The level of TARC and Eotaxin-2 in the clinical group A and group B had no significant difference （P〉0.05）.Conclusion Inflammatory response dominated by Th2-type cells ultimately leads to allergic rhinitis,but there is no significant association between levels of inflammatory cytokines and severity of allergic rhinitis.