乳腺癌术后化疗后放疗期间同期或序贯内分泌治疗的临床观察

目的 探讨乳腺癌术后化疗后放疗期间同期或序贯内分泌治疗的临床效果.方法 收集2003年1月～2007年1月本院行乳腺癌手术治疗且病理证明激素受体阳性的乳腺癌患者100例,将其分为同期组和序贯组,每组各50例.同期组给予化疗后放疗同期内分泌治疗,序贯组给予化疗后放疗序贯内分泌治疗.比较两组患者的临床疗效,随访统计两组患者毒副反应发生率及长期生存率.结果 同期组放射性肺炎、放射性肺纤维化、放射性皮肤纤维化发生率（分别为6.0％、10.0％、8.0％）与序贯组（分别为6.0％、8.0％、6.0％）比较,差异无统计学意义（P＞0.05）.同期组局部复发率（8.0％）、远处转移率（10.0％）及5年生存率（80.0％）与序贯组（分别为10.0％、14.0％、82.0％）比较,差异无统计学意义（P＞0.05）.结论 同期和序贯内分泌治疗并没有增加放疗的不良反应发生率,不会影响放疗的敏感性及总生存率.

Clinical observation on synchronization endocrine therapy or sequential endocrine therapy with radiotherapy and chemotherapy after breast cancer operation

Objective To discuss the clinical effect on synchronization endocrine therapy or sequential endocrine therapy with the radiotherapy and chemotherapy after breast cancer operation. Methods 100 patients with breast cancer in our hospital from July 2003 to January 2007 were selected,who were given breast cancer operation and proved that hormone receptor positive by pathology,they were divided into syne group and sequential group,each group had 50 cases.Sync group was given synchronization endocrine therapy with radiotherapy after chemotherapy,sequential group was given sequential endocrine therapy with radiotherapy after chemotherapy.The incidence of adverse reaction and the rate of long-telln survival of two groups were compared. Results There were no significant differences on the incidence rates of radiation pneumonitis,radiation pulmonary fibrosis and radioactive skin fibrosis in sync group （6.0%, 10.0%,8.0%） when compared with sequential group （6.0%,8.0%,6.0%）（P〉0.05）.There were no significant diffrences on local recurrence rate （8.0%）,distant metastasis rate （lO.0%）,five-year survival rate （80.0%） in sync group when compared with that in sequential group （10.0%,14.0%,82.0%）（P〉0.05）. Conclusion Synchronization or sequential of endocrine therapy is not increase the incidence of adverse reaction,and has no affection of the sensitivity of radiotherapy and the rare of overall survival.