广州地区1 403例成年女性骨密度测定分析

目的了解本地区成年女性人群腰椎、股骨近端各部位骨密度(Bone mineral density BMD)随年龄、绝经年限、体重、身高的变化规律、各部位骨密度的偏相关分析和多元线性回归分析及骨质疏松患病率情况,为骨质疏松的诊断及预防提供科学依据.方法采用美国NORLAND公司的XR-46系列双能X线骨密度仪测量1 403例成年女性人群腰椎(L2-L4前后位及L3侧位)、非优势(左)股骨近端各部位(股骨颈、大粗隆及Ward's三角)BMD值,按10岁一个年龄组分7组对数据进行统计分析.结果广州地区成年女性腰椎骨峰含量出现在30～39岁组,而股骨近端骨峰含量出现在20～29岁组,腰椎及股骨近端各部位BMD值均随年龄增长而下降,腰椎和Ward's三角部位在50～59岁和60～69岁两年龄组骨量呈快速丢失现象.各部位骨密度的偏相关分析显示各部位的骨密度均呈相关性(P＜0.01).多元线性回归分析显示年龄和体重对绝经前女性股骨颈的骨密度有影响(P＜0.01),而绝经后女性腰3侧位骨密度除了年龄和体重的影响外,身高和绝经年限均对其有影响(P＜0.01).成年女性在达到峰值骨量后随着年龄的增加,各部位骨质疏松的患病率都呈上升趋势.结论女性机体BMD随年龄而变化,年龄、体重、绝经年限及身高等对机体BMD均有一定的影响,保持合适的体重和体型,有利于BMD的增加与维持.对不同年龄段的成年女性人群,预防骨质疏松的发生应以测量不同部位的BMD作为评价手段.

Investigation of bone mineral density for 1 403 female adults in Guangzhou area

Objective To study the bone mineral density (BMD) of female's lumbar vertebrae and proximal femur changing with age, menopause duration, body weight and height; the meta analysis of relevance and regression analysis of each site's BMD values; and the prevalence rate of osteoporosis in Guangzhou area, providing scientific basis for diagnosis and prevention of osteoporosis Methods Bone mineral density of the lumbar spine and proximal femur in 1 403 female adults was measured with NORLAND XR 46 dual energy X ray absorptiometer make in USA All data were analyzed for seven age groups of ten each Results and Conclusion The peak bone mass of lumbar vertebrae in females occured in the age group 30 39, while that of proximal femur in 20 29 All BMD values decreased with increasing age BMD of each site correlated with those of other ( P <0 01) Age and body weight can influence BMD values of proximal femur in premenopausal females Besides age and body weight, the lateral third lumbar vertebra BMD value is significantly associated with body height and menopause duration The incidence of osteoporosis of each site in female adults rises with age after the peak bone mass is reached