| 色氨酸羟化酶基因多态性与单相抑郁症关系的Meta分析 |
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| 引用本文： | 吕少妮,任淑敏,王美霞等.色氨酸羟化酶基因多态性与单相抑郁症关系的Meta分析[J].医学信息学杂志,2012,33(9):40-44. |
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| 作者姓名： | 吕少妮 任淑敏 王美霞等 |
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| 作者单位： | 济宁医学院信息工程学院,日照,276826 |
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| 摘 要： | 以色氨酸羟化酶（TPH）基因和单相抑郁症应关系病倒对照的国内外文献为研究对象，应用RevMan 50对数据统计分析，综合评价色氨酸羟化酶基因多态性与单相抑郁症的关系。结果表明色氨酸羟化酶基因多态性与单相抑郁症相关，其中CC基因型是单相抑郁症的易感基因，AA基因型和AC基因型与单相抑郁症无明显关联。
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| 关 键 词： | 单相抑郁 色氨酸羟化酶基因 基因多态性 Meta分析 |
| 修稿时间： | 2012/6/27 0:00:00 |
Meta-analysis on the Relationship between TPH Gene Polymorphism and Unipolar Depression |
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| LV Shao-ni,REN Shu-min,WANG Mei-xi,ZHANG Qing,ZHU Qi-zhen,TIAN Yong-xiao.Meta-analysis on the Relationship between TPH Gene Polymorphism and Unipolar Depression[J].Journal of Medical Informatics,2012,33(9):40-44. |
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| Authors: | LV Shao-ni REN Shu-min WANG Mei-xi ZHANG Qing ZHU Qi-zhen TIAN Yong-xiao |
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| Institution: | Department of Information Engineering, Jining Medical College |
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| Abstract: | Taking the literatures on the relationship between TPH gene polymorphism and unipolar depression both in China and abroad as research objects,using the software of RevMan 5.0,the paper comprehensively evaluates the relations between TPH gene polymorphism and unipolar depression.The results show that TPH gene polymorphism has significant associations with unipolar depression, CC genotype increases the risk for unipolar depression,AA and AC genotypes are not significantly associated with unipolar depression. |
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| Keywords: | Unipolar depression TPH genetics Genes polymorphism Meta-analysis |
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