新型基因工程人肿瘤坏死因子联合足叶乙甙治疗小鼠肺癌的实验研究 |
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引用本文: | 朱旭 王春珍. 新型基因工程人肿瘤坏死因子联合足叶乙甙治疗小鼠肺癌的实验研究[J]. 武警医学, 1999, 10(9): 497-499 |
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作者姓名: | 朱旭 王春珍 |
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作者单位: | 武警云南总队医院内二科!昆明650111(朱旭,龙惠萍),武警甘肃总队医院(王春玲),解放军第四军医大学唐都医院(王琳,楚东岭) |
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摘 要: | 目的 探讨新型基因工程人肿瘤坏死因子(nrh T N F) 和足叶乙甙( V P- 16) 的协同抗肿瘤作用及nrh T N F 的毒副作用。方法 以复制成功的 Lewis 肺癌(3 L L) 小鼠为模型局部用药。结果 nrh T N F 或 V P- 16 瘤体内注射均能使肿瘤生长及肺转移受到一定的抑制,抑瘤率分别为3371 % 、3046 % ,肺转移瘤数与对照组比较 P < 005 ,肿瘤出现一定程度坏死。而联合用药则能显著抑制肿瘤生长及肺转移,抑瘤率为6577 % ,大于理论抑瘤率5391 % ,肺转移瘤数与对照组比较 P < 001 ,肿瘤出现广泛的出血坏死。同时观察到nrh T N F 对实验小鼠无明显毒副作用。结论 nrh T N F 和 V P- 16联合应用,具有协同抗肿瘤作用,对于肺癌治疗具有进一步临床应用探讨价值。目的 探讨新型基因工程人肿瘤坏死因子(nrh T N F) 和足叶乙甙( V P- 16) 的协同抗肿瘤作用及nrh T N F 的毒副作用。方法 以复制成功的 Lewis 肺癌(3 L L) 小鼠为模型局部用药。结果 nrh T N F 或 V P- 16 瘤体内注射均能使肿瘤生长及肺转移受到一定的抑制,抑瘤率分别为3371 % 、30
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关 键 词: | 人肿瘤坏死因子 足叶乙甙 肺癌人肿瘤坏死因子 足叶乙甙 肺癌 |
Therapeutic effect of new recombinant human tumor necrosis factor combined with etoposide on m urine lung carcincoma |
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Abstract: | Objective To investigate the effect of new recombinant human tumor necrosisfactor(nrh T N F) combined with etoposide( V P- 16) on inhibition of murine lung cancer and the side effect of T N Fin experimental mice . Methods Tumor- bearing mice wererandomly divided into four groups ,normalsaline ,nrh T N F, V P- 16 and nrh T N Fplus V P- 16 were injected into the neoplasm ofthe fourgroups rospectively . Four mice of each group were killed 14 days afterinoculation after,neoplasms were detected underlight microscope ;others were killed after 21 days inoculation ,neoplasms were weighted ,and lung metastatic tumors were counted . Results Both nrh T N Fand V P- 16 inhibited the growth and lung metastasis of murine 3 L Ltumor,inhibition ratesin nrh T N Fgroup and V P- 16 group were 33 .71 % and 30 .46 % ,respectively ,and tumor necrosis resulted to a certain degree . The lung metastatic tumors in the groups mentionedabove were fewer than in control group ( P < 0 05) . Afavourable out- come was observed in the animals treated with nrh T N F/ V P-16 ,i.e .lower tumor growth rate (inhibition rate 65 .77 % ) and more extensivetumor hemonagic necrosis oppeareathan in control group( P < 0 01) .nrh T N Fprodtced no marked side ef |
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Keywords: | Recombinant human tumor necrosisfactor Etoposide Lung cancer |
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