| 肝硬化大鼠黑质一氧化氮合酶阳性神经元分布的研究 |
| |
| 引用本文： | 陈亚亮,陆涛,马育平,宋一志,万华英,高秀来.肝硬化大鼠黑质一氧化氮合酶阳性神经元分布的研究[J].解剖学研究,2002,24(1):19-20,27. |
| |
| 作者姓名： | 陈亚亮 陆涛 马育平 宋一志 万华英 高秀来 |
| |
| 作者单位： | 首都医科大学解剖学教研室,北京,100054 |
| |
| 摘 要： | 目的 研究肝硬化大鼠黑质一氧化氮合酶 (NOS)阳性神经元及纤维分布的变化。方法 2 0只Wistar大鼠随机分为肝硬化组与正常组 ,应用NADPH d组化法显示肝硬化大鼠黑质NOS阳性神经元胞体的数量及胞体灰度。结果 肝硬化大鼠黑质一氧化氮合酶阳性神经元数量明显减少但阳性胞体的灰度增加 ,正常组大鼠黑质一氧化氮合酶阳性神经元数量增加但胞体的灰度降低。结论 肝硬化大鼠体内有毒物质使脑细胞广泛受损 ,神经递质传递发生障碍 ,造成肝性脑病的一系列神经系统病症
|
| 关 键 词： | 一氧化氮合酶 黑质 肝硬化 大鼠 |
Study of distribution of nitric oxide synthase(NOS)positive nuerons in substantia nigra of rats with cirrhosis of liver |
| |
| Chen Yaliang,Lu Tao,Ma Yuping,Song Yizhi,Wan Huaying,Gao Xiulai.Study of distribution of nitric oxide synthase(NOS)positive nuerons in substantia nigra of rats with cirrhosis of liver[J].Anatomy Research,2002,24(1):19-20,27. |
| |
| Authors: | Chen Yaliang Lu Tao Ma Yuping Song Yizhi Wan Huaying Gao Xiulai |
| |
| Institution: | Chen Yaliang,Lu Tao,Ma Yuping,Song Yizhi,Wan Huaying,Gao Xiulai.Department of Anatomy,Affiliate of Capital University of Medical Science.Beijing 100054 China |
| |
| Abstract: | Objective To observe the nitric oxide synthase(NOS)positive nuerons and distribution of NOS fibers in substantia nigra of rats with cirrhosis of liver.Methods Wistar rats were divided to 2 groups with 10 rats in each one:control(normal rats)and rats with cirrhosis of liver.The areas of NOS positive nuerons and the gray scale of cell body in substantia nigra of rats with cirrhosis of liver were analyzed by NADPH d.Results Compared with the controls,the quantity of NOS positive nuerons decreased and the gray scale of cell body increased statistically.Conclusion The toxins in rats with cirrhosis of liver may damage neurons extensively,impair the transmission of neurotransmitters,and cause pathologic changes such as hepatic encephalopathy. |
| |
| Keywords: | Nitric oxide synthase(NOS) Susbstantia nigra Cirrhosis of liver Rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
