Further experience with radiation therapy and concomitant intravenous chemotherapy in advanced carcinoma of the lower female genital tract |
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Authors: | William S Roberts MD Mitchel S Hoffman MD John J Kavanagh MD James V Fiorica MD Harvey Greenberg MD Michael A Finan MD Denis Cavanagh MD |
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Institution: | H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612. |
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Abstract: | Sixty-seven patients with advanced carcinoma of the lower female genital tract (cervix, vagina, and vulva) were treated with radiation and concomitant intravenous cisplatin and/or 5-fluorouracil. Fifty-seven patients (85%) responded completely clinically. Thirty-five (61%) complete responders recurred with a median time to recurrence of 6 months. Twenty-six of the thirty-five patients who recurred had some component of local failure. The 22 complete responders who have not recurred have been followed a median of 13 months. Acute toxicity was minimal, with only 6 patients requiring interruption of therapy. Nine (13%) patients developed severe late complications and eight required surgery. The actuarial 5-year survival is 22%. This treatment regimen is disappointing in terms of both survival and local control. |
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