| 胃癌组织雌激素受体定位及其生物学意义 |
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| 引用本文： | 罗克枢,陈玉琼,黄晓赤,赵剑萍,高冬明. 胃癌组织雌激素受体定位及其生物学意义[J]. 西南国防医药, 1995, 0(1) |
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| 作者姓名： | 罗克枢 陈玉琼 黄晓赤 赵剑萍 高冬明 |
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| 作者单位： | 成都军区总医院病理科，成都军区总医院病理科，成都市第六人民医院病理科，成都市第六人民医院病理科，成都市第六人民医院病理科 610083，610083 |
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| 摘 要： | 采用免疫组化ABC法对89例胃癌、10例癌旁和11例胃溃疡旁粘膜组织进行了雌激素受体(ER)检测。结果发现:①癌旁和溃疡旁粘膜上皮均为ER阴性,胃癌组织ER阳性率达33.7％,其ER颗粒在细胞内分布呈核型、浆型和核浆型;②胃癌Borrmann Ⅳ型、低分化癌和伴淋巴结转移的胃癌,其ER阳性率明显高于其它类型(P<0.05或P<0.01)。研究表明,ER阳性表达的胃癌与其恶性生物学行为有正相关性。
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| 关 键 词： | 胃癌 雌激素受体 |
LOCALIZATION OF ESTROGEN RECEPTORS IN GASTRIC CANCER AND IT'S BIOLOGICAL SIGNIFICANCE |
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| Luo Keshu,et al.. LOCALIZATION OF ESTROGEN RECEPTORS IN GASTRIC CANCER AND IT'S BIOLOGICAL SIGNIFICANCE[J]. Medical Journal of National Defending forces in Southwest China, 1995, 0(1) |
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| Authors: | Luo Keshu et al. |
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| Affiliation: | Luo Keshu,et al. Department of pathology,chengdu Army General Hospital,Chengdu,610083 |
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| Abstract: | Using immunohistochemical method, estrogen recptor(ER) was studied in 89 cases of gastric cancer, 10 cases of gastric paracancer mucosas and 11 cases of gastric paraulcer mucosas. The results were found: (1) the epithelium mucosas of paracancer and paraulcer were ER-negative > and ER -postive rate of gastric cancer tissue was 33- 7%. ER-particulates localised in nucleus or cytoplasma, or both nucleus and cytoplasma of cancer cells; (2) the ER postive rates in Herrmann's IV type of gastric cancer, poorly - differentiated cancer and cancer with metastasis to lymph node were significant higher than other types (P<0. 05 P<0. 01). The present study showed that gastric cancer of ER -postive was correlative to it's malignant biologic behavior. |
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| Keywords: | gastric cancer estrogen receptor(ER) |
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