卵巢癌患者内源性阿片肽与红细胞免疫粘附作用的实验研究

检测了三组受检者的红细胞免疫粘附性及血浆中内源性阿片肽的含量,其中卵巢恶性肿瘤30例,良性肿瘤27例,正常对照组22例。结果发现:恶性组RC3bRR和R-TRR较良性和正常人降低(P<0.01),而RICR则上升(P<0.01)。其血浆中β—内啡肽含量较良性和正常人明显升高(P<0.001),而强啡肽、脑亮啡肽在三组中无明显变化(P>0.05)。同时还发现卵巢恶性肿瘤患者的RC3bRR及R—TRR与β-内啡肽呈显著负相关(r=-0.6467,P<0.01;r=-0.4264,P<0.05),RICR与β—内啡肽无明显相关。提示卵巢恶性肿瘤患者的红细胞免疫粘附性低下与其血浆中β—内啡肽含量升高有关。

CORRELATION BETWEEN RBC IMMUNE FUNCTION AND EOP IN THE PATIENTS WITH OVARIAN TUMOR

The relationships between the red blo6d cell immune function,and endogenous opioid peptides(EOP)in the three groups,30malignant ovarian tumor,27 benign tumor,22 normal control persons were termined. We found that RC3bRR and R-TRR ofmalignant ovarian tumor group were lower than those of the benign and control group (P<0. 01). The RICR and B-endophin (B-EP) ofmalignant group were higher than those of benign and control groups (P<0. 01 and P<0. 001 respectively). There was no significant change of the contents of Dynorphin Al-13 and L-Enkephalin in three groups. It should be noted that RCSbRR and R-TRR of themalignant group were negatively correlated to 3-EP (r = - 0. 6467,P<0. 01,r=-0. 4262,P<0. 05),while RICR of themalignant group was not significantly correlated to B-EP (r = 0.1170,P>0.05). It suggests that the decreased RBC immune functionmight be related with the elevation of B-EP in the blood of the patients withmalignant ovarian tumor.