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The inhibitory principle of lipopolysaccharide-induced nitric oxide production from<Emphasis Type="Italic">inula britannica</Emphasis> var.<Emphasis Type="Italic">chinensis</Emphasis>
Authors:Kang-Hoon?Je  Ah-Reum?Han  Hyun-Tai?Lee  Woongchon?Mar  Email author" target="_blank">Eun-Kyoung?SeoEmail author
Institution:Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
Abstract:A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an iNOS inhibitory constituent for the first time with an IC50 value of 22.1 microM which is more potent than the positive control, L-N6-(1-iminoethyl)lysine (IC50 = 33.7 microM). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.
Keywords:Inula britannica L  var  chinensis (Rupr  ) Reg    Compositae  1-O-acetyl-4R            6S-britannilactone  iNOS inhibitor
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