| Influence of Stent Implantation on the Expression of PCNA and Apoptosis in Injured Vascular Smooth Muscle Cells |
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| 作者姓名： | 刘英梅 张旭明 伍卫 王景峰 陈筱潮 |
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| 作者单位： | Department，of cardiology，Sun yat - Sen Memorial Hospital. Sun Yat - Sen University，Guangzhou 510120，P R China The grant from Sanitation Department Science Foundation of Guangdong，Department，of cardiology，Sun yat - Sen Memorial Hospital. Sun Yat - Sen University，Guangzhou 510120，P R China The grant from Sanitation Department Science Foundation of Guangdong，Department of cardiology，Sun yat - Sen Memorial Hospital. Sun Yat - Sen University，Guangzhou 510120，P R China The grant from Sanitation Department Science Foundation of Guangdong，Department，of cardiology，Sun yat - Sen Memorial Hospital. Sun Yat - Sen University，Guangzhou 510120，P R China The grant from Sanitation Department Science Foundation of Guangdong，Department，of cardiology，Sun yat - Sen Memorial Hospital. Sun Yat - Sen University，Guangzhou 510120，P R China The grant from Sanitation Department Science Foundation of Guangdong |
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| 摘 要： | Objectives To evaluate the impact of stent implantation on proliferation and apop-tosis in injured media vascular smooth muscle cells (VSMC) and to explore the mechanism of restenosis after stent implantation. Methods Fifty male New Zealand rabbits were randomized into two groups, including balloon group and stent group. Control group was set up. The samples were harvested on 3, 7, 14, 28, 56 days after operation and the following investigation was carried out: (1) Assessing the expression of proliferating cell nuclear antigen (PCNA) of media VSMC by the method of immunohistochemistry; (2) Analyzing apoptosis of media VSMC by DNA agarose gel electrophoresis and TUNEL technique. Results The expression of PCNA and apoptosis in stent and balloon groups were markedly increased compared with control groups. (1) Stent group induced significant increased expression of PCNA in the media VSMC compared with balloon group on 3 to 28 days. On day 7, the positive rates of PCNA were 24. 36±0. 55 % vs 18. 74±1. 09 %
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Influence of Stent Implantation on the Expression of PCNA and Apoptosis in Injured Vascular Smooth Muscle Cells |
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| LIU Ying - mei ZHANG Xu - ming WU Wei WANG Jing - feng,CHEN Xiao -chao.Influence of Stent Implantation on the Expression of PCNA and Apoptosis in Injured Vascular Smooth Muscle Cells[J].South China Journal of Cardiology,2002(2). |
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| Authors: | LIU Ying - mei ZHANG Xu - ming WU Wei WANG Jing - feng CHEN Xiao -chao |
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| Institution: | LIU Ying - mei ZHANG Xu - ming WU Wei WANG Jing - feng
CHEN Xiao -chao
Department of cardiology,Sun yat - Sen Memorial Hospital. Sun Yat - Sen University,Guangzhou 510120,P R China
The grant from Sanitation Department Science Foundation of Guangdong |
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| Abstract: | |
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| Keywords: | Restenosis Stent Vascular smooth muscle cells (VSMC) Proliferating cell nu-clear antigen (PCNA) Apoptosis |
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