| 尼莫地平对急性缺血性脑损伤的干预机制 |
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| 引用本文： | 王兴勇,卢仲毅,李晓文.尼莫地平对急性缺血性脑损伤的干预机制[J].儿科药学杂志,2003,9(1):1-3. |
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| 作者姓名： | 王兴勇 卢仲毅 李晓文 |
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| 作者单位： | 重庆医科大学附属儿童医院,重庆,400014 |
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| 基金项目： | 重庆市教育委员会基金资助项目(项目号:991654) |
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| 摘 要： | 目的：探讨尼莫地平对急性缺血性脑损伤的保护作用。方法：将局灶性脑缺血模型大鼠分为假手术组，缺血组及尼莫地平干预组。测定脑组织PLA2活力，脑细胞内游离Ca^2 浓度，脑含水量及脑组织PLA2表达量的改变。结果：尼莫地平可使缺血后脑细胞内游离Ca^2 浓度，PLA2活性及脑组织含水量明显降低。但对脑缺血后脑组织PLA2mRNA表达降低不明显。结论：尼莫地平能抑制PLA2活性，降低细胞内游离Ca^2 浓度，减轻脑水肿病理改变，对缺血性脑细胞损害有一定保护作用。
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| 关 键 词： | 尼莫地平 脑缺血 干预机制 |
| 文章编号： | 1672-108X(2003)01-0001-03 |
| 修稿时间： | 2002年12月21 |
Protective effect of nimodipine on acute cerebral ischemia injury |
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| ANG Xingyong,LU Zhongyi,Li Xiaowen.Protective effect of nimodipine on acute cerebral ischemia injury[J].Journal of Pediatric Pharmacy,2003,9(1):1-3. |
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| Authors: | ANG Xingyong LU Zhongyi Li Xiaowen |
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| Institution: | Children' s Hospetial of Chongqing University of Medical Science 400014 |
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| Abstract: | Objective: To study the protective effect of nimodipine on acute cerebral ischemia injury. Methods: Rats after cerebral middle artery occlussion was divided into three groups: bogus operated groups, ischemia groups and nimodipin protective groups, and the phos-pholipase A2 (PLA2) activity, cytosolic free Ca2+ concentrations, brain water contents and the expression of sPLA2-IIA mRNA and the cPLA2-IV mRNA in cerebral cortex were examined. Results: The PLA2 activity, cytosolic free Ca2+ concentrations in neuronal cells, and brain water contents were progressively decreased, but the expression of sPLA2-IIA mRNA and the cPLA2-IV mRNA in cerebral cortex was not progressively decreased after used nimodipine. Concision: The protective effect of nimodipine has been found in refraining PLA2 activity and lowering cytosolic free Ca2+ concentrations on acute cerebral ischemia injury and easing final pathologic changes of brain water contents. |
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| Keywords: | Nimodipine Cerebral ischemia |
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