Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension |
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| Authors: | Rejdak Robert Kohler Konrad Kocki Tomasz Shenk Yana Turski Waldemar A Okuno Etsuo Lehaci Cristiana Zagorski Zbigniew Zrenner Eberhart Schuettauf Frank |
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| Affiliation: | Department of Pathophysiology of Vision and Neuro-Ophthalmology, Division of Experimental Opthalmology, University Eye Hospital, R?ntgenweg 11, 72076 Tübingen, Germany. rrejdak@yahoo.com |
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| Abstract: | The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension. |
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| Keywords: | Kynurenic acid Kynurenine aminotransferases Glaucoma Retinal degeneration DBA/2J mice |
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