Treatment outcomes of oxaliplatin, 5-FU, and leucovorin as salvage therapy for patients with advanced or metastatic gastric cancer: a retrospective analysis |
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Authors: | Hee Yeon Seo Dae Sik Kim Yoon Seok Choi Hwa Jung Sung Kyong Hwa Park In Keun Choi Seok Jin Kim Sang Cheul Oh Jae Hong Seo Chul Won Choi Byung Soo Kim Sang Won Shin Yeul Hong Kim Jun Suk Kim |
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Institution: | (1) Division of Oncology–Hematology, Department of Internal Medicine, Korea University Medical Center, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5 ga, Seongbuk-gu, Seoul, 136-705, South Korea |
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Abstract: | Purpose We performed a single-institution retrospective study to evaluate the efficacy and toxicities of oxaliplatin, 5-fluorouracil
(5-FU), leucovorin (LV) combination chemotherapy as salvage treatment in patients with metastatic or advanced gastric cancer.
Methods Sixty-two patients with advanced gastric cancer previously treated were eligible for the study. Patients received oxaliplatin
100 mg/m2 and LV 100 mg/m2 (2-h intravenous infusion) followed by 5-FU 2,400 mg/m2 (46-h continuous infusion) every 2 weeks, and responses were assessed after every three cycles.
Results Fifty-nine out of 62 patients were assessable for response. Among them, 46 patients had previously been treated with cisplatin
based chemotherapy. Patients had a median age of 57 years (range 32–76 years), 72.6% had an Eastern Cooperative Oncology Group
performance status of 0 or 1. Total 296 courses of chemotherapy were administered as second-line (67.7%) or third-line (27.4%),
and the median courses per patient was three cycles. Out of 59 evaluable patients, 14 partial responses were observed (overall
response rate, 22.6%). Stable disease was observed in 22 patients (35.5%), and progressive disease in 23 patients (37.1%).
The median response duration, time to progression, and overall survival were 2.3, 3.0, and 8.0 months, respectively. The major
toxicities were neutropenia, mucositis, and peripheral neuropathy. Grade 3 or 4 hematologic toxicities included neutropenia
in nine patients (14.5%) and thrombocytopenia in one patient (1.6%). Other grade 3 or 4 toxicities included mucositis in one
patient (1.6%) and vomiting in two patients (3.2%). Grade 1 or 2 peripheral neuropathy were observed in 18 patients (29.0%),
however there were no cases of grade 3 or 4 peripheral neuropathy and no treatment-related deaths.
Conclusion The combination of oxaliplatin, 5-FU and LV was effective and safe salvage chemotherapy in advanced gastric cancer patients. |
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Keywords: | Oxaliplatin 5-Fluorouracil Salvage therapy Gastric cancer |
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