3种疗程三联疗法根除十二指肠溃疡病人幽门螺杆菌感染的比较(英文)

目的 :通过与 7d三联疗法比较 ,观察 3d和 5d三联疗法根除幽门螺杆菌 (Hp)和治疗十二指肠溃疡的疗效。方法 :116例经胃镜检查确诊为十二指肠溃疡活动期并经快速尿素酶试验和血清抗Hp抗体 (ELASE)或病理学检查确定为Hp阳性的病人分为 3组 :3d(3d组 ,39例 )和 5d试验组 (5d组 ,37例 )和 7d对照组 (7d组 ,4 0例 )。 3组均给予三联治疗 :雷贝拉唑 10mg +呋喃唑酮 10 0mg +克拉霉素 2 5 0mg ,每日 2次 ,疗程分别为 3,5和 7d ,后再给予雷贝拉唑 10mg ,每日 1次 ,3d组为 2 5d ,5d组为 2 3d ,7d组为 2 1d。并于抗Hp方案结束后d 2 8～ 5 6内作13C 尿素呼气试验判断Hp根除率的效果。同时在用药后d 1,3,5 ,7,2 1和 35对病人的上腹痛、反酸以及上腹烧灼感等症状进行评估。结果 :10 7例病人完成全部治疗方案 ,9例失访 ,3,5 ,7d组人数分别为 37,35 ,35例。Hp根除率 3d组为 76 % (2 8/ 37) ,5d组为 89% (31/ 35 ) ,7d组为91% (32 / 35 ) ,5d组和 7d组之间差异无显著意义(P >0 .0 5 ) ,且均高于 3d组 (P <0 .0 5 )。3组从用药d 1起均能有效改善病人的上腹痛、反酸、上腹烧灼感等症状 ,各组症状缓解率无显著差异 (P >0 .0 5 )。结论 :3组治疗方案均能有效缓解十二指肠溃疡病人的症状 ,而根除Hp ,5d和 7d疗程较 3d疗程为优

Cmparison of eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies

AIM: To observe the effect of eradicating Helicobacter pylori (Hp) and treating duodenal ulcer by 3 d and 5 d triple therapies through comparing with the 7 d triple therapy. METHODS: One hundred and sixteen patients who were confirmed in duodenal ulcer active period by gastroscopy and Hp positive confirmed by rapid urease test, serum anti-Hp antibody (ELASE) or histological examination were divided into three groups: 3 d group (n=39), 5 d group (n=37) and 7 d controlled group (n=40). All three groups were provided triple therapy first: rabeprazole 10 mg furazolidone 100 mg clarithromycin 250 mg, bid, for 3, 5, and 7 d, respectively. Then rabeprazole 10 mg was provided once a day. The period of 3, 5 and 7 d group was 25, 23, and 21 d, respectively. Twenty-eight day to 56 d after taking the medicine, 13C urea breath test was performed to judge the effect of Hp eradication rate. In d 1, 2, 3, 7, 21,35, the symptoms of patients such as epigastralgia, burning pain and acidity were evaluated simultaneously. RESULTS: One hundred and seven patients accomplished all therapy scheme, 9 patients lost. There are 37, 35 and 35 patients in 3,5,7 d group accomplished therapy, respectively. The examination results indicated that the Hp eradication rate of each group was as follows: 3 d group was 76 %(28/37), 5 d group was 89 %(31/35), 7 d group was 91 % (32/35). There was no significant difference between 5 d and 7 d group (P> 0.05). But the Hp eradication rate of the two groups was obviously higher than that of 3 d group (P<0.05). The symptoms such as epigastralgia, burning pain and acidity in all three groups improved since the first day. There was no significant difference in total score descending of symptoms among each group (P>0.05). CONCLUSION: All the three therapy schemes can alleviate symptoms of duodenal ulcer patients efficiently. But as far as eradicating Hp concerned, the scheme of 5 d and 7d is better than that of 3 d.