Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma |
| |
Authors: | Vernino Steven Tuite Paul Adler Charles H Meschia James F Boeve Bradley F Boasberg Peter Parisi Joseph E Lennon Vanda A |
| |
Institution: | Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. verns@mayo.edu |
| |
Abstract: | Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|