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Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity
Authors:Chen Ping  Doweyko Arthur M  Norris Derek  Gu Henry H  Spergel Steven H  Das Jagabundhu  Moquin Robert V  Lin James  Wityak John  Iwanowicz Edwin J  McIntyre Kim W  Shuster David J  Behnia Kamelia  Chong Saeho  de Fex Henry  Pang Suhong  Pitt Sydney  Shen Ding Ren  Thrall Sara  Stanley Paul  Kocy Octavian R  Witmer Mark R  Kanner Steven B  Schieven Gary L  Barrish Joel C
Affiliation:Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
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