乳铁蛋白对小鼠的辐射防护作用

目的 研究乳铁蛋白对辐射损伤小鼠的保护作用。方法 小鼠随机分成3组,空白对照组、单纯照射组、给药组。给予6.8Gy照射剂量小鼠30d观察各组存活率实验;给予2Gy照射剂量观察各组小鼠的骨髓微核率并对有核细胞进行计数。结果 单纯照射组小鼠照后死亡率较高,25d全部死亡,与给药组比较存活时间差异有统计学意义(P < 0.05),一般情况也有统计学意义(P < 0.05)。单纯照射组照后小鼠骨髓有核细胞数明显下降,而乳铁蛋白给药组(包括照前给药和照后给药)高于单纯照射组,比较差异有统计学意义(P < 0.05)。单纯照射组照后3d小鼠骨髓的微核细胞率明显升高,而乳铁蛋白给药组低于单纯照射组,比较差异有统计学意义(P < 0.05)。结论 乳铁蛋白无论是照前给药还是照后给药都具有较好的抗辐射作用。

The Radioprotective Effect of Human Lactoferrin in Mice

Objective To study the effect of human lactoferrin on the X-ray Radiation Injury in mice. Methods The mice were randomly divided into three groups:control group,radiation group and l1actoferrin group. To give mice 6.8 Gy, observe mice'30 d survival rate and to give mice 2 Gy,observe bone marrow micronucleus, nuclear cell count. Results All the mice of radiation group without Lactoferrin died in 25d after exposure. The group the 30-day livability is high,there was a significant difference in comparison between radiatin group without lactoferrin and groups with lactoferrin (P < 0.05). In the group without lactoferrin, the bone marrow karyocytes decreased significantly after radiation, and lf treatment groups (including prevention and emergency) are higher than pure radiation group, there was a significant difference in comparison between radiatin group without lactoferrin and groups with lactoferrin (P < 0.05). Simply after radiation for 3 days, mice micronucleus bone marrow cells shouwed a significantly higher rate, and the group without lactoferrin, it shouwed less than the group with lactoferrin, with significant difference (P < 0.05). Conclusion lactoferrin which is used in the prevention iron or emergency to has radioprotective effect.