PTENp53及hTERT在I型子宫内膜癌中的表达

目的：探讨PTEN、p53及hTERT在I型子宫内膜癌中的表达，为子宫内膜癌的早期诊断和治疗提供理论依据。方法：应用免疫组织化学SABC法同步检测49例子宫内膜癌中的p53、PTEN、hTERT的表达，取同期49例正常的子宫内膜组织做对照，数据采用SPSSl3．0软件处理，计数资料进行x检验，等级资料进行秩和检验。结果：PTEN蛋白在子宫内膜癌中阳性表达率为40．8％，低于正常子宫内膜组97．9％，且阳性表达与子宫内膜癌的组织分级、FIGO分期、淋巴转移、肌层浸润深度呈负相关；相反，hTERT和p53两种蛋白在子宫内膜癌组阳性表达率（67．3％、38．8％）均高于正常子宫内膜组，并子宫内膜癌恶性程度及FIGO分期呈正相关。结论：与正常子宫内膜相比，PTEN在子宫内膜癌中表达减少，而P53及hTERT呈表达升高，三者均可作为子宫内膜诊断及判定预后的标记物。

Expression of PTEN p53 and hTERT in Type I Endometrial Carcinoma

Objective： To investigate the expression of PTEN, p53 and hTERT in type I endometrial carcinoma, find the evidence for early diagnosis and treatment of endometrial carcinoma. Method： A total of 49 specimens of endometrial carcino- ma and 49 normal endometrium were studied by immunohistochemical method to test the expression of p53, PTEN and hTERT. SPSS13.0 software was used for data processing. Chi-square test was used for numeration data, rank sum test for ranked data. Result： Positive expression rate of PTEN protein in endometrial carcinoma was 40.8%, which was lower than that in normal endometrium （97.9% ）. Positive expression of PTEN was negatively correlated with tumor grade, FIGO stage, lymphatic metas- tasis and muscular infiltration of endometrial carcinoma, positive expression rate of hTERT and p.53 protein in endometrial carci- noma was 67.3% and 38.8% respectively, which were higher than the normal endometrium, and they were positively correla- ted with FIGO stage and malignancy of endometrial carcinoma. Conclusion： Compared to normal endometrium, PTEN expres- sion was decreased in endometrial carcinoma, while p53 and hTERT expression were increased. All of the three protein could act as diagnostic and prognostic marker for endometrial carcinoma.