高血压病患者应用阿托伐他汀颈动脉内膜中层厚度及脉压差的影响

摘要：目的：探讨阿托伐他汀对高血压患者动脉内膜中层厚度及脉压差的影响。方法：将单纯性收缩期高血压160例，随机分为治疗组和对照组各80例，对照组1：7服厄贝沙坦（150mg1次／日，治疗组在对照组基础上，加用阿托伐他汀20rag，1次／晚，治疗12个月，观察两组患者血压及动脉内膜中层厚度。结果：治疗后治疗组颈总动脉（CCA）、颈动脉分叉处（BULB）的颈动脉内膜中层厚度和脉压差均明显低于对照组，差异有明显的统计学意义（P〈0．05）。结论：高血压病患者应用阿托伐他汀不但能降低颈动脉内膜中层厚度，而且可以改善脉压差情况。

Effect of Atorvastatin on Intima-media Thickness of the Common Carotid Artery and Pulse Pressure in Patient with Hypertensive Disease

Objective： To study the effect of atorvastatin on intima-media thickness of the common carotid artery and pulse pressure in hypertensive disease patient. Method： 160 patients with isolated systolic hypertension, were randomly divided into treatment group and control group, with 80 cases in each group, The control group was treated with irbesartan （ 150rag once a day, the treatment group on the basis of the control group, combined with atorvastatin 20mg, once per nigh for 12 months ob- served two groups blood pressure and intima media thieknes. Result：Carotid artery （ CCA} , carotid bifurcation （ BUI,B} of the carotid artery intima-media thickness and pulse pressure were significantly lower than those in the control group in post-treat- ment, there was statistically significant difference （ P 〈 0.05 ）. Conclusion： Atorvastatin treatment not only regresses the struc- tural changes in intima-media thickness common carotid artery but also improve disorder pulse pressure of hypertensive disease patient.