异维A酸红霉素凝胶联合螺内酯治疗寻常型痤疮临床观察 |
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引用本文: | 杜金锋,裴广德,熊伟,甄希,杜军波,汪光明. 异维A酸红霉素凝胶联合螺内酯治疗寻常型痤疮临床观察[J]. 河北医学, 2013, 0(12): 1764-1767 |
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作者姓名: | 杜金锋 裴广德 熊伟 甄希 杜军波 汪光明 |
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作者单位: | 河南省焦作市焦作煤业集团有限责任公司中央医院门诊部皮肤科,河南焦作454000 |
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摘 要: | 目的:观察异维A酸红霉素凝胶联合螺内酯治疗寻常型痤疮的疗效和安全性。方法:将入选的147例轻、中度寻常型痤疮患者随机分为治疗组和对照组,两组均在睡前外用异维A酸红霉素凝胶1次,疗程8周;治疗组同时还予螺内酯片,20mg,tid与餐同服。在治疗2、4和8周后观察疗效和不良反应。结果:治疗2周后,两组的有效率分别为20.83%和14.29%,差异无统计学意义(P〉O.05);4、8周后,治疗组有效率(54.17%,80.56%)均显著高于对照组(30.00%,54.29%),差异均有统计学意义(P〈O.01)。药物相关不良反应主要为局部刺激症状,两组发生率分别为31.08%、29.58%,差异无统计学意义(P〉O.05)。结论:异维A酸红霉素凝胶联合螺内酯治疗轻、中度寻常型痤疮疗效肯定、安全、不良反应少,价格低廉,值得推广应用。
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关 键 词: | 寻常型痤疮 异维A酸 红霉素 螺内酯 |
Clinical Study of Isotretinoin Erythromycin Gel Combined Spironolactone in the Treatment of Acne Vulgaris |
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Affiliation: | DU Jinfeng, PEI Guangde, XIONG Wei, et al { The Central Hospital of Jiaozuo Coal Group, Henan Jiaozuo 454000, China ) |
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Abstract: | Objective: To evaluate the efficacy and safety of isotretinoin erythromycin gel united spironolactone in acne vulgaris. Method: 147 patients with the mild or moderate acne vulgaris were randomly divided into treatment group (n = 75 } and control group( n =72). They were topically treated with isotretinoin erythromycin gel once daily in the evening for 8 weeks, while the treatment group were treated with spironolactone,29mg was taken orally with the meal,3 times per day. And they were followed up on the 2,4,8 weeks after starting treatment. Result: The response rates of two groups were 20.83% and 14.29% respectively within 2 weeks after treatment, and there was no statistical significance ( P〉0.05 }. The effectiveness rates for the treatment group{ 54.17% ,80.56% ) were significantly higher than those in control roup { 30.00% ,54.29% ) within 4 and 8weeks respectively ( P〈O. O1 ). The drug related adverse reactions mainly is local irritation symptoms ,and the incidence was 31. 08% ,29.58% respectively,there was no statistically significant difference between the two groups. Conclusion: The treatment of isotretinoin erythromycin gel united spironolactone is effective, safe, with less adverse reaction and lower price, It's worth pop- ularizing and applying in the mild or moderate acne vulgaris. |
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Keywords: | Acne vulgaris Isotretinoin Erythromycin Spironolactone |
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