| Wnt信号通路在足细胞中的作用和调节机制 |
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| 引用本文： | 吴影懿,邢昌赢,张波.Wnt信号通路在足细胞中的作用和调节机制[J].中华临床医师杂志(电子版),2014(4):738-741. |
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| 作者姓名： | 吴影懿 邢昌赢 张波 |
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| 作者单位： | 南京医科大学第一附属医院(江苏省人民医院)肾内科,210029 |
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| 基金项目： | 国家自然科学基金资助项目（81170660）;国家自然科学基金青年基金项目（81100512） |
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| 摘 要： | Wnt信号通路在细胞的分化、增殖和凋亡等生理过程中以及在细胞癌变、肿瘤侵袭等病理过程中均发挥了重要的调控作用。最近研究显示,Wnt信号通路在肾脏疾病发展和上皮细胞特化中起重要作用,在损伤等不同的疾病条件下该通路被激活。基因修饰动物模型研究表明,在足细胞中Wnt信号通路持续激活通常与蛋白尿和肾小球硬化的进展有关。本文就Wnt信号在足细胞中的作用和调节机制作一综述。
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| 关 键 词： | 足细胞 细胞转分化 Wnt/β-catenin信号通路 |
The role and regulation of Wnt signaling in podocytes |
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| Wu Yingyi,Xing Changying,Zhang Bo.The role and regulation of Wnt signaling in podocytes[J].Chinese Journal of Clinicians(Electronic Version),2014(4):738-741. |
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| Authors: | Wu Yingyi Xing Changying Zhang Bo |
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| Institution: | . ( Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China) |
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| Abstract: | Wnt signaling plays a role in a variety of physiological processes that involve cell differentiation, proliferation, apoptosis and in the pathological process of carcinogenesis and tumor invasion. Recent studies have shown that Wnt signaling pathway promotes kidney disease in specialized epithelial cells and the pathway is activated in different disease conditions of the injury. Genetically modified animal models showed that the podocytes sustained activation of Wnt signaling pathway usually associated with proteinuria and glomerular sclerosis progress. Here, we discuss the role and regulation mechanism of Wnt/β-catenin signaling in podocytes. |
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| Keywords: | Podocytes Cell transdifferentiation Wnt/β-catenin signaling |
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