内镜下硬化剂注射联合普萘洛尔治疗食管胃底静脉曲张破裂出血的临床研究

目的：观察肝硬化食管胃底静脉曲张破裂出血患者,内镜下硬化剂注射联合口服普萘洛尔与单纯内镜下硬化剂注射,治疗止血成功率及再出血发生率。方法：入选有效随访患者115例,其中59例采用硬化剂注射治疗,56例采用硬化剂注射联合口服普萘洛尔治疗,全部患者观察12个月,比较两组间的止血成功率及再出血发生率。结果：硬化剂治疗组及联合治疗组治疗前各级别构成及Child-Pugh评分值组间比较,差异无统计学意义（P〉0.05）。硬化剂治疗组及联合治疗组的止血成功率差异无统计学意义（P〉0.05）。但再出血发生率,联合治疗组较硬化剂治疗组明显降低（P〈0.05）。结论：硬化剂治疗组及联合治疗组均有较高止血成功率,联合治疗组可显著降低再出血发生率。

The clinical study of treatment of esophageal and gastric varices bleeding by endoscopic injection scolerotherapy combined with propranolol

Objective：To observe the cirrhotic patients with bleeding esophageal varices endoscopic sclerotherapy combined with oral propranolol,and simple endoscopic sclerotherapy hemostasis success rate and rebleeding rate.Methods：115 patients were selected for effective follow-up,59 were treated with sclerotherapy,and 56 were treated with sclerother apy combined with oral propranolol therapy,all patients observed for 12 months,compared the success rate of bleeding be tween the two groups and re-bleeding incidence.Results：The sclerotherapy group and combined treatment group before treatment and at all levels constitutes the value of Child-Pugh score differences between groups was not significant（P〈0.05）.Sclerotherapy group and combined treatment group success rate of hemostasis was no significant difference（P〉0.05）.However,rebleeding rate,combined treatment group than in the sclerotherapy group was significantly lower（P〉0.05）.Conclusion：The sclerotherapy group and combined treatment group has a higher success rate of bleeding,combination therapy significantly reduce rebleeding rate.