精神分裂症患者血清同型半胱氨酸水平及临床意义

目的探讨精神分裂症患者血清同型半胱氨酸（Hcy）水平及临床意义。方法选择2013年8月1～31日北京市昌平区中西医结合医院（以下简称＂我院＂）精神分院收治的符合国际疾病分类（ICD）精神分裂症诊断标准的患者803例作为观察组,另选择我院同期健康体检者289名作为对照组。两组采用循环酶法进行血清Hcy浓度测定,并进行统计学分析。结果观察组803例精神分裂症患者血清Hcy水平高于正常范围的有570例,高同型半胱氨酸血症的发生率为70.98%;对照组289名体检人群中血清Hcy水平高于正常范围的有107例,高同型半胱氨酸血症的发生率为37.02%;观察组高同型半胱氨酸血症发生率高于对照组（χ^2=22.836,P〈0.01）;观察组患者血清Hcy水平为（21.69±11.33）μmol/L,对照组血清Hcy水平为（16.84±11.14）μmol/L,两组比较差异有统计学意义（t=10.362,P〈0.01）。观察组男、女患者血清Hcy水平分别为（24.71±11.64）、（18.30±9.10）μmol/L,均明显高于对照组[（17.45±10.93）、（14.90±9.92）μmol/L],差异均有统计学意义（t=12.036、5.284,均P〈0.01）。结论精神分裂症患者中存在有明显的Hcy代谢异常,但Hcy代谢失衡与精神分裂症关系的生物学机制需要进一步研究。

Serum homocysteine level of patients with schizophrenia and its clinical significance

Objective To discuss the serum homocysteine（Hcy） level of patients with schizophrenic and its clinical significance. Methods 803 cases accord with schizophrenia diseases diagnostic criteria of International Classification of Diseases treated in Psychiatric Branch, Changping Hospital of Integrated Chinese and Western Medicine（＂our hospital＂ for short） were selected as observation group from August 1 to 31, 2013. 289 cases of healthy control were selected as control group. The serum Hcy level was detected by circulating enzymatic method, and the results were analyzed.Results Among 803 cases with schizophrenic in the observation group, 570 cases had higher serum Hcy level, the incidence of hyperhomocysteinemia was 70.98%. Among 289 healthy control in the control group, 107 cases had higher serum Hcy level, the incidence of hyperhomocysteinemia was 37.02%. The incidence of hyperhomocysteinemia in the observation group was higher than that in the control group, the difference was statistically significant（χ^2=22.836, P〈0.01）. The serum Hcy levels in the observation group and the control group were（21.69±11.33） μmol/L and（16.84±11.14） μmol/L retrospectively, the difference was statistically significant（t = 10.362, P〈0.01）. In the observation group, the serum Hcy levels of male and female were（24.71±11.64） μmol/L and（18.30±9.10） μmol/L retrospectively,which were all higher than those of male and female in the control group [（17.45±10.93）,（14.90±9.92） μmol/L], the differences were statistically significant（t = 12.036, 5.284, P 0.01）. Conclusion Schizophrenic patients have obviously Hcy metabolic abnormalities, but the biological mechanism of relationship between Hcy metabolism disturbance and schizophrenia need further study.