动脉粥样硬化患者血清IL-6与ADMA水平变化及其临床意义

目的探讨动脉粥样硬化患者(AS)血清IL-6与ADMA水平变化及其与疾病发生、发展的关系。方法收集本院门诊45例AS患者和30例健康对照者标本,采用ELISA法检测血清IL-6与ADMA的浓度水平。结果 AS患者组血清中IL-6的浓度水平明显高于健康对照组,结果分别为(31.43±8.2)和(9.59±2.71)/pg/ml,差异有统计学意义(P0.05);而AS患者组血清中ADMA的浓度水平也明显高于健康对照组,结果分别为(3.16±0.53)和(1.29±0.21)/μmol/ml,差异有统计学意义(P0.05)。AS组血清IL-6的敏感性为80.0%,ADMA的敏感性为86.7%,2项指标联合检测AS敏感性达95.6%。结论 IL-6与ADMA可能参与AS的发生与发展,且可能对AS的诊断有一定的临床意义。

Changes and clinical significance of serum IL-6 and ADMA level in patients with AS

Objective To investigate the changes of serum IL-6 and ADMA level in the pathologic process of atherosclerosis（AS）. Methods Serum level of IL-6 and ADMA were detected by ELISA of 45 AS patients and 30 healthy controls from Zhaoqing Municipal First People＇s Hospital. Results Serum level of IL-6- in AS patients was statistically higher than that in healthy controls, the results of IL-6 were （31.43±8.2） and（ 9.59±2.71）/pg/ml, showing significant difference between the two groups （P 〈0.05） ; and ADMA in AS patients was statistically higher than that in healthy controls, the results of ADMA were （3.16±0.53） and （1.29±0.21）/umol/ml, showing significant difference （P 〈0.05）. The sensitivity of IL-6 and ADMA in diagnosis of AS were 80.0% and 86.7%, respectively, the sensitivity was increased to 95.6% when IL-6 and ADMA were combined detexcted.Conclusion Serum IL-6 and ADMA might be involved in the pathogenesis of AS and they might be indicators for diagnosis of AS.