PCDGF、CD44v6、IC1M-1在结肠癌的表达及意义

目的探讨畸胎瘤细胞源性生长因子（PC cell-derivedgrowthfactor，PCDGF）、CD44v6、细胞间黏附分子-1（Intercellularadhesionmolectile-1，／CAM-1）在结肠癌中的表达水平及其临床意义。方法应用免疫组化法检测40例结肠癌组织和40例癌旁非癌组织中PCDGF、CD44v6、ICAM-1的表达水平，并进行综合分析。结果癌组织PCDGF、CD44v6、ICAM-1表达率分别为62．5％（25／40）、52．5％21/40）和62．5％（25／40），明显高于癌旁组织中的5．0％（2／40）、7．5％（3／40）和5．0％（2／40），差异有统计学意义（χ2=-27．1，17．2，27．1，P均〈0．01）。PCDGF、CD44v6、ICAM-1在癌组织表达率与淋巴结转移、远处转移及Dukes分期有关，与组织分化程度、浸润深度无关。结论结肠癌中PCDGF、CD44v6、ICAM-1的表达水平明显升高，三者参与了结肠癌的发生及转移过程。

Expression of PCDGF,CD44v6, ICAM-1 in human colon cancer and its clinical significance

Objective To investigate the clinical significance of PC cell-derived growth factor（PCDGF）, CD44v6, intercellular adhesion molecule-l（iCAM-1） in colon carcinoma. Methods Expression of PCDGF, CD44v6,ICAM-1 in specimens of cancer tissue of 40 patients was examined by immunohistochernical（S-P） method. Results The expression levels of PCDGF, CD44v6, ICAM-lwere 62.5% （25/40）, 52.5%（21/40）and 62.5%（25/40）, which were obviously higher than that in cancer tissue （5.0%, 2/40; 7.5 %, 3/40 and 5.0%, 2/40） showing statistical significant difference （X2=-27.1,17.2,27.1, P〈0.01） The correlation between expression rate of PCDGF, CD44v6, ICAM-1 and lymph node metastasis, distant metastasis and Dukes classification was observed. But it was not related with histological type, infiltration depth. Conclusion PCDGF, CD44v6, ICAM-1 was overexpressed in colon carcinoma. PCDGF, CD44v6, ICAM-1 were involved in carcinogenesis and metastases.