精神分裂症患者血清总胆汁酸水平及临床意义

目的探讨精神分裂症患者血清总胆汁酸（TBA）的表达及临床意义。方法选取2012年1月～2014年1月北京市昌平区中西医结合医院精神病分院住院患者200例为精神分裂症组,选择健康体检的人群100例作为健康体检组,使用循环酶法测定血清TBA的浓度。结果①精神分裂症组患者TBA水平（13.3±4.2）μmol/L]明显高于健康体检组（5.2±2.3）μmol/L],差异有统计学意义（t=4.863,P〈0.05）;精神分裂症组ALT为（33.8±8.5）U/L,AST为（34.4±8.7）U/L,与健康体检组（29.8±7.8）U/L及（30.4±8.1）U/L]比较,差异无统计学意义（t=1.285、1.457,P〉0.05）。②精神分裂症组男性患者TBA水平为（13.2±4.1）μmol/L,女性患者为（13.7±4.4）μmol/L,两者间TBA水平差异无统计学意义（t=1.066,P〉0.05）;男性患者ALT和AST分别为（35.6±8.8）U/L和（37.2±9.0）U/L,女性患者分别为（31.5±8.1）U/L和（30.8±7.9）U/L,男女患者ALT和AST水平比较差异无统计学意义（t=0.904、1.358,P〉0.05）。③精神分裂症组患者用药前TBA水平为（13.3±4.2）μmol/L,用药后为（18.2±5.2）μmol/L,用药前后TBA水平差异有统计学意义（t=2.769,P〈0.05）;用药前ALT和AST分别为（33.8±8.5）U/L和（34.4±8.7）U/L,用药后ALT和AST分别为（34.2±8.6）U/L和（36.5±8.9）U/L,差异均无统计学意义（t=1.386、1.525,P〉0.05）。结论血清TBA的测定可以作为临床上监测精神分裂症患者用药的一个重要参考指标,测定精神分裂症患者血清TBA浓度对减少抗精神病药物的毒副反应具有一定的指导意义,同时,血清TBA也是一项在临床上相当有实用价值的肝功能检验指标。

Clinical application and determination of serum TBA in patients with schizophrenia

Objective To investigate the expression and clinical significance of serum total bile acid（TBA） in patients with schizophrenia. Methods 200 patients with schizophrenia from January 2012 to January 2014 in Changping Hospital of Integrated Chinese and Western Medicine were selected as schizophrenia group, 100 cases of health examination in the same term were chose as health examination group, serum TBA was measured in the two groups by enzymatic cycling method. Results ①The TBA level in schizophrenia group （13.3±4.2） μmol/L] was higher than that of health examination group （5.2±2.3） μmol/L], the differences were statistically significant（t = 4.863, P〈0.05）; the ALT and AST levels in schizophrenia group were（33.8±8.5） U/L and（34.4±8.7） U/L respectively, the ALT and AST levels in health examination group were（29.8±7.8） U/L and（30.4±8.1） U/L respectively, the differences were not statistically significant（t = 1.285, 1.457, P〉0.05）. ②The TBA level in male patients in schizophrenia group was（13.2±4.1） μmol/L,the TBA level in female patients was（13.7±4.4） μmol/L, the difference was not statistically significant（t = 1.066, P〉0.05）; the ALT and AST levels of male patients in schizophrenia group were（35.6±8.8） U/L and（37.2±9） U/L, the ALT and AST levels of female patients in schizophrenia group were（31.5±8.1） U/L and（30.8±7.9） U/L, the differences were not statistically significant（t = 0.904, 1.358, P〉0.05）. ③The TBA levels in schizophrenia group before and after the treatment were（13.3±4.2） μmol/L and（18.2±5.2） μmol/L, the differences were statistically significant（t = 2.769, P〈0.05）;the ALT and AST levels before the treatment in schizophrenia group were（33.8±8.5） U/L and（34.4±8.7） U/L, the ALT and AST levels in schizophrenia group after treatment were（34.2±8.6） U/L and（36.5±8.9） U/L, the differences were notstatistically significant（t = 1.386, 1.525, P〉0.05）.Conclusion The serum T