肺结核患者IL-15和效应性CD8+T细胞的检测及意义

目的 通过检测肺结核患者IL-15水平及其效应性CD8+T细胞的变化,探讨IL-15在结核病免疫保护和结核病病情进展中的作用.方法 对98例肺结核患者进行血清IL-15水平及效应性CD8+T细胞检测,并结合痰涂片、病变程度等进行分析.结果 肺结核患者初治、复治组IL-15水平及效应性CD8+T细胞的百分比计数均较正常对照组下降(P<0.05或P<0.01),复治组IL-15水平及效应硅CD8+T细胞的百分比计数低于初治组(P值均<0.01);肺结核患者重度组IL-15水平及效应性CD8+T细胞百分比计数明显低于轻、中度组(P值均<0.01).痰菌阳性、痰菌阴性两组间II-15水平及效应性CD8+T细胞百分比计数比较差异无统计学意义.结论 IL-15有望为结核病病情判断、内源性复发的评估提供一个新的指标.

Detection and significance of interleukin-15 and effector CD8+T cells in patients with pnimonary tuberculosis

Objective To study the roles of interleukin-15(IL-15)in the immunoprotection and tuberculosis progress by detecting the serum levels of IL-15 and the percentages of effector CD8+ T cells in the patients with pulmonary tuberculosis.Methods The serum levels of IL-15 and the percentages of effector CD8+ T cells in 98 patients were detected,and analyzed according to the degrees of disease severity and the sputum smear. Results the serum levels of IL-15 and the percentages of effector CD8+ T cells in the patients of the first-time treatment group and the re-treatment group were lower than those in the control group(P<0.05 or P<0.01).The serum levels of IL-15 and the percentages of effector CD8+ cells in the re-treatment group were lower than those in the first-time treatment group(all P<0.01).The serum levels of IL-15 and the percentages of effector CD8+ T cells in patients with severe degree of pulmonary tuberculosis were lower than those in the patients with medium and mild degrees pulmonary tuberculosis(all P<0.01).However,there were no significant difference in the serum levels of IL-15 and the percentages of effector CD8+ T cells between the smear positive group and the smear negative group.Conclusions IL-15 might be a new index in assessing disease severity and recurrence in the patients with pulmonary tuberculosis.