| L—赖氨酸锌在犬体内药代动力学实验研究 |
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| 引用本文： | 朱志国 贾玉玺. L—赖氨酸锌在犬体内药代动力学实验研究[J]. 微量元素与健康研究, 1996, 13(1): 10-11 |
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| 作者姓名： | 朱志国 贾玉玺 |
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| 作者单位： | 空军医学高等专科学校 |
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| 摘 要： | 用原子吸收法测定Ｌ－赖氨酸锌和硫酸锌在大体内血清锌浓度，用一级动力学和一室模型分析Ｌ－赖氨酸锌和硫酸锌的药代动力学基本参数。结果表明，Ｌ－赖氨酸锌的血清锌峰浓度、曲线下面积和相对生物利用度都明显优于硫酸锌，其他各参数两组基本相似，说明Ｌ－赖氨酸锌是一优于硫酸锌的理想补锌药物。
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| 关 键 词： | L－赖氨酸锌，药代动力学，原子吸收法 |
Experimental Studies on Pharmacokinetics of Zinc L-lysinate in Dogs |
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| hu Zhiguo,Jla Yuxi,Zhang Xiaoyun,Xi Kesheng,Liu Jutao,Liu Weiming. Experimental Studies on Pharmacokinetics of Zinc L-lysinate in Dogs[J]. Studies of Trace Elements and Health, 1996, 13(1): 10-11 |
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| Authors: | hu Zhiguo Jla Yuxi Zhang Xiaoyun Xi Kesheng Liu Jutao Liu Weiming |
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| Affiliation: | The Air Force Medical College Jilin l320ll |
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| Abstract: | Serum zinc conccntration of zinc L-lysinate and zinc sulfdte in dogs are determintld by Atomic Absorption Spectophomctry.basi parameters of pharmacokinetics of zinc L-lysinate and zinc sulfate are analysed by first order roder reaction kinetics and mod-el of,simple in this paper, The results showed the peak of serum zinc concentration ,the area of peak and relative bioavailability of zinc L-lysinate was supeior to zinc sulfate,other bdsic paramaters was similar to the two groups ,this conclusion explained zinc L -lsinate was a better drug to supply trace elements zinc suprior to zinc sulfate. |
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| Keywords: | zine L-lysinate pharmacokinetics Atomic Absorption Spectophometry |
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