Seizures following picornavirus infection |
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Authors: | Libbey Jane E Kirkman Nikki J Smith Matthew C P Tanaka Tomoko Wilcox Karen S White H Steve Fujinami Robert S |
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Affiliation: | Departments of Pathology;and Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, U.S.A. |
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Abstract: | Purpose : We demonstrate the establishment and characterization of a novel virus infection-induced seizure model in C57BL/6 mice. Methods: C57BL/6 mice were infected with Theiler's murine encephalomyelitis virus (TMEV) or mock infected. Mice were followed for seizures, weight change, body temperature, motor function (righting reflex, rotorod) and neurological manifestations (inflammation [perivascular cuffing], pyknotic neurons, transforming growth factor [TGF]-β expression). Results: C57BL/6 mice are susceptible to seizures induced by TMEV infection. Approximately 50% of C57BL/6 mice develop transient afebrile seizures. Motor function and coordination are impaired in seized mice. Pyramidal neuron pyknosis and TGF-β expression correlate with seizure activity in the hippocampus. Discussion: The characterization of this model will enable the investigation of viral and immune contributions in the central nervous system to the development of seizure disorders in humans. |
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Keywords: | Theiler's murine encephalomyelitis virus Seizures Epilepsy |
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