视网膜色素变性的吲哚青绿血管造影特征

目的研究视网膜色素变性(retinitis pigmentosa,RP)的脉络膜血液循环特征。方法对37例RP患者行吲哚青绿血管造影(indocyanine green angiogra phy,ICGA)，并与正常人眼对照。结果①RP组眼底荧光最早出现的平均时间(14.38±3.95) s，脉络膜静脉荧光开始充盈的平均时间(17.27 ±5.94) s，与对照组比较差异无显著性的意义(P>0.05)。 ②RP组脉络膜血管荧光减弱的平均时间(475.75±153.70) s，较对照组明显缩短(P<0.0001)。③RP组眼底后部强荧光区的平均面积(41.20±19.99) mm²，较对照组明显缩小(P<0.0001)。④ICGA中后期RP组纱幕状荧光缺如61只 眼，占84.7%；斑状强荧光21只眼占29.2%，4只眼强荧光点渗漏，占5.6%。结论①RP脉络膜血管灌注压无改变；②RP脉络膜血流量减少；③RP脉络膜毛细血管萎缩；④RP可伴有脉络 膜新生血管形成。(中华眼底病杂志,2001,17:26-29)

Characteristics of retinitis pigmentosa in indocyanine green angiography

Objective　To study the characteristics of choroidal circulation in RP.　Methods　Using ICGA to observe 37 cases of RP and compare with healthy volunteers.　Results　① The earliest fluores-cein filling time of the choroidal arteries in RP group was (14.38±3.95) seconds,the choroidal veinous in RP group was (17.27±5.94) seconds,and there was no obvious difference between RP and control group.②The fluorescein failing time of choroidal vein in RP group was (475.75±153.70)seconds.③The area of the bright fluorenscence in posterior fundus in RP group was (41.20±19.99)　mm2,and compared with the control group,there was significant difference (P＜0.0001).④In the mid to late phase during ICGA，in RP group the veil-like hypofluorescence was found in 61 eyes (84.7%),plaque hyperfluorescence in posterior fundus in 21 eyes (29.2%),and leakage of heperfluorescence in 4 eyes(5.6%).　Conclusion　①The perfusion pressure of choroidal vessels in RP reveals no change.②The blood volume of choroidal vessels becomes decreased in RP.③The choroidal capillaries become atrophic in RP.④Choroidal neovascularization may occur in patients with RP.