Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus |
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| Authors: | Milan Flekac Jan Skrha Jirina Hilgertova Zdena Lacinova Marcela Jarolimkova |
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| Affiliation: | (1) 3rd Dept. of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic |
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| Abstract: | Background Reactive oxygen species generated by hyperglycaemia modify structure and function of lipids, proteins and other molecules taking part in chronic vascular changes in diabetes mellitus (DM). Low activity of scavenger enzymes has been observed in patients with DM. Protective role of scavenger enzymes may be deteriorated by oxidative stress. This study was undertaken to investigate the association between gene polymorphisms of selected antioxidant enzymes and vascular complications of DM. |
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