| 葛根总黄酮缓释片的多组分体外释放度研究 |
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| 引用本文： | 石峰,朱春燕. 葛根总黄酮缓释片的多组分体外释放度研究[J]. 中国中药杂志, 2008, 33(12): 1396-1398 |
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| 作者姓名： | 石峰 朱春燕 |
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| 作者单位： | 中国医学科学院,中国协和医科大学药用植物研究所,北京,100094 |
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| 基金项目： | 国家高技术研究发展计划--生物与现代农业技术领域创新药物和中药现代化重大专项 |
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| 摘 要： | 目的：研究葛根总黄酮缓释片中多组分体外释放度，探索中药缓释制剂的评价方法。方法：采用转篮法测释放度，HPLC进行指纹图谱分析，监测多组分释药特征。结果：建立了葛根总黄酮缓释片体外释放度的HPLC指纹图谱，通过对8个时间点体外释放液的测定研究，发现多组分的体外释放基本一致，具有均一性。结论：本法简便、重现性好，可用于评价葛根总黄酮缓释制剂体外释放度。
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| 关 键 词： | 葛根总黄酮 缓释片 释放度 |
| 收稿时间： | 2007-12-26 |
Drug release of sustained-released tablets of total puerariae flavones |
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| SHI Feng; ZHU Chun-yan. Drug release of sustained-released tablets of total puerariae flavones[J]. China Journal of Chinese Materia Medica, 2008, 33(12): 1396-1398 |
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| Authors: | SHI Feng ZHU Chun-yan |
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| Affiliation: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, China. |
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| Abstract: | Objective: To study drug release of susained-released tablets of total puerariae flavones and investigate the evaluating method of sustained released preparations Chinese material medica susained-released preparation. Method: Rotating basket method and HPLC were employed to assess the characteristics of multi-component. Result: Under the selected chromatographic conditions, good HPLC fingerprint of the release of susained-released tablets of total puerariae flavones were obtained. Through the determination of 8 time-point samples,the release of susained-released tablet of total puerariae flavones had a well-balanced release behavior. Conclusion: The HPLC-UV fingerprint method was simple and reproducide, quality of tablets of total puerariae flavones can be controlled effectively by the method. The method could be applied to evaluate the the release of susained-released tablets of total puerariae flavones. |
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| Keywords: | total puerariae flavones susained-released tablets release behavior |
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