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CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis |
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| Authors: | Andreas Carlborg Jussi Jokinen Erik G. Jönsson Sophie Erhardt Peter Nordström |
| Affiliation: | 1. Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska University Hospital Solna, SE-171 76 Stockholm, Sweden;2. Department of Physiology and Pharmacology, Karolinska Insitutet, Stockholm, Sweden |
| Abstract: | Relationships between concentrations of cerebrospinal fluid (CSF) kynurenic acid (KYNA) and suicidal behavior were evaluated in 59 patients with psychosis after 22 years of follow-up. Three patients died from suicide and nine patients had a history of attempted suicide. Patients with attempted suicide had significantly lower concentrations of CSF KYNA. |
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