阿托伐他汀钙片仿制药与原研药治疗高脂血症的疗效与经济学评价

目的:比较阿托伐他汀钙片仿制药(阿乐)与原研药(立普妥)治疗高脂血症的临床疗效和经济学评价.方法:选取2017年1月至2019年12月重庆市黔江中心医院收治的高脂血症患者150例,采用随机数字表法将患者分为观察组(75例)和对照组(75例).对照组患者给予阿托伐他汀钙片原研药(立普妥)20 mg/d;观察组患者给予阿托...

Efficacy and Economic Evaluation of Atorvastatin Calcium Tablets Generics and Original Drugs in the Treatment of Hyperlipidemia

OBJECTIVE:To compare the clinical efficacy and economic effects of Atorvastatin calcium tablets generics(Ale)and original drugs(Lipitor)in the treatment of hyperlipidemia.METHODS:Totally 150 patients with hyperlipidemia admitted into Qianjiang Central Hospital of Chongqing from Jan.2017 to Dec.2019 were extracted to be divided into the observation group and the control group via the random number table,with 75 cases in each group.The control group was given Atorvastatin calcium tablets original drugs(Lipitor)20 mg/d,while the observation group received Atorvastatin calcium tablets generics(Ale)20 mg/d.Both groups were treated for 24 weeks.Blood lipidstriglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)levels]of two groups were detected.The clinical efficacy and safety of drug treatment between two groups were compared,and the drug economy was evaluated.RESULTS:Compared with before treatment,the plasma TC,TG and LDL-C levels of two groups decreased significantly after treatment,while the plasma HDL-C levels increased significantly,with statistically significant differences(P<0.05).After treatment,there was no significant difference in TG,TC,LDL-C and HDL-C levels between two groups(P>0.05).The total effective rates of lipid regulation in the observation group and control group were 92.00%(69/75)and 94.67%(71/75),respectively.The incidence of adverse drug reactions in the observation group and the control group were respectively 10.67%(8/75)and 12.00%(9/75),the difference was not statistically significant(P>0.05).The total costs of the observation group and the control group were respectively 92.40 and 1026.48 yuan,and the cost-effectiveness ratios were respectively 1.01 and 10.84.Taking observe group as the reference,the incremental cost-effectiveness ratio was positive number,indicating that the cost of the control group(Lipitor group)decreased,and its drug efficacy also decreased,therefore,the observation group(Ale group)was the most economical.Sensitivity analysis(10%reduction in drug costs)results were consistent with the results of cost-effectiveness analysis.CONCLUSIONS:Both Atorvastatin calcium tablets generics(Ale)and primordia(Lipitor)are effective in the treatment of hyperlipidemia with higher safety,yet generics(Ale)have more pharmacoeconomic advantages.