抗体类免疫诱导剂在实体器官移植中的应用现状

器官移植是治疗终末期器官衰竭的首选有效治疗方法,然而器官移植术后早期急性排斥反应往往是导致移植失败的重要因素。为了减少器官移植后排斥反应的发生,往往需要在移植前或移植中加用强效免疫抑制剂对受体免疫系统进行抑制性诱导治疗。抗体类免疫诱导剂作为器官移植早期实施覆盖性免疫抑制治疗的常用方法,可显著减少器官移植术后早期急性排斥反应的发生,同时可延迟或减少钙调磷酸酶抑制剂类药物的应用,有利于保护肾功能、促进移植物功能恢复及受者长期存活。本文就抗体类免疫诱导剂在实体器官移植中的应用现状作一综述。

Application of antibody inducers in solid organ transplantation

Organ transplantation is the first effective treatment for end-stage organ failure.However,early acute rejection after organ transplantation is often an important factor leading to transplantation failure.In order to reduce the incidence of rejection after organ transplantation,it is often necessary to use potent immunosuppressants to induce the immune system of recipients before or during transplantation.As a common method of covering immunosuppressive therapy in the early stage of organ transplantation,antibody immunoinducers can significantly reduce the occurrence of early acute rejection after organ transplantation,and delay or reduce the application of calcineurin inhibitor drugs,which is conducive to protecting renal function,promoting graft function recovery and long-term survival of recipients.This article reviews the application of antibody inducers in solid organ transplantation.