艾司奥美拉唑镁肠溶片联合胶体果胶铋胶囊及阿莫西林胶囊在老年功能性消化不良患者中的应用及对营养状态、胰岛素样生长因子1的影响研究

目的:探讨艾司奥美拉唑镁肠溶片联合胶体果胶铋胶囊及阿莫西林胶囊在老年功能性消化不良(functional dyspepsia,FD)患者中的应用及对营养状态、胰岛素样生长因子1(IGF-1)的影响。方法:选取2015年1月至2019年1月应急总医院消化内科诊治的老年FD患者104例作为研究对象,以随机数字表法分为对照组(52例)和观察组(52例)。对照组患者采用艾司奥美拉唑镁肠溶片治疗,观察组患者在对照组的基础上联合胶体果胶铋胶囊及阿莫西林胶囊治疗。治疗15 d后对治疗效果进行评估;治疗后对患者进行6个月随访,比较两组患者近端胃功能参数、营养状态、胃动力学指标水平、不良反应发生情况及复发情况。结果:观察组患者治疗15 d后的近端胃功能参数(阈值饮水量、阈值近端胃容积、饱足饮水量和饱足近端胃容积)及IGF-1水平明显高于对照组,差异均有统计学意义(P<0.05);观察组患者治疗15 d后的餐后4、6 h胃排空率,血红蛋白、前白蛋白及白蛋白水平明显高于对照组,差异均有统计学意义(P<0.05)。两组患者血压波动、肝肾异常和头晕嗜睡等不良反应发生率及1个月复发率的差异均无统计学意义(P>0.05);观察组患者3、6个月复发率明显低于对照组,差异均有统计学意义(P<0.05)。结论:艾司奥美拉唑镁肠溶片联合胶体果胶铋胶囊及阿莫西林胶囊用于老年功能性消化不良患者,能提高患者胃功能及胃动力学水平,有助于改善其营养状态,未增加不良反应,且能降低治疗后复发率。

Application of Esomeprazole Magnesium Enteric-Coated Tablets Combined with Colloidal Bismuth Pectin Capsules and Amoxicillin Capsules in Elderly Patients with Functional Dyspepsia and its Effects on Nutritional Status and IGF-1 Level

OBJECTIVE:To probe into the application of Esomeprazole magnesium enteric-coated tablets combined with Colloidal bismuth pectin capsules and Amoxicillin capsules in elderly patients with functional dyspepsia(FD)and its effects on nutritional status and insulin-like growth factor-1(IGF-1)level.METHODS:Totally 104 elderly patients with FD admitted into gastroenterology department of Emergency General Hospital from Jan.2015 to Jan.2019 were selected and divided into control group(52 cases)and observation group(52 cases)via random number table.The control group was treated with Esomeprazole magnesium enteric-coated tablets,while the observation group was given Colloidal bismuth pectin capsules and Amoxicillin capsules based on the control group,evaluation on therapeutic effect was conducted after 15-day treatment,and 6-month follow-up was conducted after treatment.The proximal gastric function parameters,nutritional status,indicators of gastric dynamics,incidence of adverse drug reactions and recurrence were compared between two groups.RESULTS:The proximal gastric functionparameters(threshold water intake,threshold proximal stomach volume,satiety water intake and satiety proximal stomach volume)and IGF-1 level of observation group after 15-day treatment were significantly higher than those of the control group,with statistically significant differences(P<0.05);the 4 h and 6 h postprandial gastric emptying rates,hemoglobin,prealbumin and albumin levels of observation group after 15-day treatment were significantly higher than those of the control group,with statistically significant differences(P<0.05).There were no statistical significance in differences in 1-month recurrence rate and the incidence of adverse drug reactions such as blood pressure fluctuations,liver and kidney abnormalities,dizziness and sleepiness between two groups(P>0.05);the recurrence rates at 3 and 6 month after treatment in observation group were significantly lower than those of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:The application of Esomeprazole magnesium enteric-coated tablets combined with Colloidal bismuth pectin capsules and Amoxicillin capsules for elderly patients with functional dyspepsia can improve the gastric function and gastric dynamics,which is conducive to improve the nutritional status and reduce the recurrence rate after treatment,without increasing adverse drug reactions.