奥沙利铂加白介素-2腹腔热化疗联合静脉化疗治疗老年癌性腹腔积液的临床研究

目的研究奥沙利铂(L-OHP)加白介素-2(IL-2)腹腔热化疗联合静脉化疗治疗老年癌性腹腔积液的疗效和不良反应.方法将42例消化系统肿瘤来源的癌性腹腔积液患者引出腹腔积液后,在加热的5%葡萄糖溶液2 000～2 500 mi中加入L-OHP 85 ms/m2及IL-2(2 MU),用NRL-002型内生场肿瘤热疗系统行腹部局部热疗,腹腔内温度保持在41～43℃,持续60～120 min.腹腔热化疗后第2天,给予静脉化疗,予以亚叶酸钙(CF)0.2 s/m2静滴2 h,氟尿嘧啶(5-FU)0.4 s/m2静推,1.6 g/m2持续静脉输注46 h,每2周重复.结果42例患者近期治疗总有效率为66.67%,其中完全缓解(CR)6例,部分缓解(PR)22例,稳定(NC)6例,无效(PD)8例,中位生存时间(MST)为5.6个月,主要毒性表现为急性腹痛、麻痹性肠梗阻.结论L-OHP加IL-2腹腔热化疗联合静脉化疗治疗老年癌性腹腔积液具有一定的疗效,不良反应轻,且能提高患者生存质量,值得进一步研究.

Clinical study of hyperthermic peritoneal perfusion with oxaliplatin and interleukin-2 combined with chemotherapy for treatment on malignant ascites in eider patients

Objective To evaluate the effects and toxicities of the hyperthermic peritoneal peffusion with oxaliplatin (L-OHP) and interleukin-2 (IL-2) combined with chemotherapy for treatment malignant asci-tes. Methods 42 patients with malignant aacites from assimilation system tumor were catheterized,drained and flushed with L-OHP 85 mg/m2 in 2 000 ～2 500 ml of 5 % glucose and IL-2(2 MU),NRL-001 Double RF tumor hyperthermia system was applied to heat the abdominal part for 60 ～ 120 minutes at an intraperitoneal temperature of 41 -43 ℃ ,next day,all the patients were treated with calcium folinate(CF)0. 2 g/m2 by 2 hours intravenous infusion,5-fluorouracil (5-FU) 0. 4 g/m2 intravenously, followed by 46 hours continuous infusion of 5-FU (1 600 mg/m2), 2 weeks a cycle. Results The overall response rate was 66. 67%, including CR : 6 cases, PR:22 cases, NC:6 cases, and PD:8 cases. MST is 5.6 months. The main toxicity was impatient abdomen ache,paralysis intestinal obstruction. Conclusion Hyperthermic peritoneal perfusion with oxaliplatin and inter-leukin-2 combined with chemotherapy is efficient and safe in the treatment malignant ascites and can improve the quality of life. It is worthing wildly using and research.