| 固本通络冲剂治疗IgA肾病的实验研究 |
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| 引用本文： | 周家俊,高建东,何立群,郑平东.固本通络冲剂治疗IgA肾病的实验研究[J].中国中西医结合肾病杂志,2003,4(8):442-444. |
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| 作者姓名： | 周家俊 高建东 何立群 郑平东 |
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| 作者单位： | 上海中医药大学附属曙光医院肾内科,上海,200021 |
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| 基金项目： | 上海市科委科研基金(No.964319025) |
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| 摘 要： | 目的：在中药复方固本通络冲剂治疗IgA肾病取得显临床疗效的基础上，进行动物实验以探讨其临床疗效作用机理。方法：采用口服0．1％牛血清白蛋白及静注葡萄球菌肠毒素B制成的小鼠IgA肾病模型。并用固本通络冲剂进行治疗并分析其作用机理。结果：动物实验表明固本通络冲剂降低蛋白尿作用与临床结果一致，对肾组织病理损害、肾组织SOD、GSH—PX活性、MDA含量亦有显改善作用。结论：固本通络冲剂作用机理可能与提高活性氧清除酶类的活性，减少肾组织过氧化脂质，从而减轻肾组织病理损害有关。
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| 关 键 词： | 固本通络冲剂 中医药治疗 IgA肾病 动物实验 小鼠 肾功能 |
| 修稿时间： | 2002年10月28 |
The Study of Gubentongluochongji on Experimental IgA Nephropathy |
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| ZHOU Jiajun,GAO Jiandong,HE Liqun,et al.The Study of Gubentongluochongji on Experimental IgA Nephropathy[J].Chinese Journal of Integrated Traditional and Western Nephrology,2003,4(8):442-444. |
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| Authors: | ZHOU Jiajun GAO Jiandong HE Liqun |
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| Abstract: | Objective:To study the mechanism of Chinese herbal compoud Gubentongluochongji(GBTLCJ)on experimental IgA Nephropathy(IgAN). Methods: Forty BALB/C male mices were randomized into four groups: normal control group, IgAN control group,GBTLCJ treated group and persantin control group. We observed its effect of treatment on mice with IgAN was induced by oral 0.1% BSA and intravenous SEB. Results: Animal experimental study indicated:GBTLCJ not only decreased proteinuria.but al so had aignificaut effects in ameliorating renal lesion and regulating the metabolism of SOD, GSH- PX and MDA.Conclusion:GBTLCJ is an effective Chinese herbal compoud on IgAN.The mechanism may include increasing SOD and GSH- PX,resisting lipid peroxidation in renal tissue and ameliorating renal lesion. |
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| Keywords: | Gubentongluochontji(GBTLCJ) IgA Nephropathy( IgAN) Effective mechanism |
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