| 维奥欣对冠心病人血浆内皮素氧化修饰低密度脂蛋白的影响 |
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| 引用本文： | 丁秀华,商月茹,张栩,崔云双.维奥欣对冠心病人血浆内皮素氧化修饰低密度脂蛋白的影响[J].浙江中西医结合杂志,2002,12(2):74-75. |
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| 作者姓名： | 丁秀华 商月茹 张栩 崔云双 |
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| 作者单位： | 山东省滨州地区人民医院,滨州,256610 |
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| 摘 要： | 目的 :观察维奥欣对冠心病人血浆内皮素 (ET)、氧化修饰低密度脂蛋白 (ox LDL)水平的影响。方法 :5 7例冠心病人随机分为维奥欣组和消心痛组。消心痛组仅口服消心痛 ,维奥欣组在口服消心痛同时加服维奥欣片剂。两组患者治疗前后测 ET、ox LDL的变化 ,同时取 2 5例健康人做对比。结果 :治疗前维奥欣组和消心痛组中冠心病人 ET、ox LDL水平明显高于健康人组。治疗后两组患者临床症状均明显好转 ,维奥欣组二项指标均较消心痛组明显下降 (P<0 .0 5 )。结论 :维奥欣片具有良好的抗心肌缺血作用 ,其作用机制可能与调整 ET、ox LDL代谢 ,改善内皮细胞功能有关。
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| 关 键 词： | 冠心病 内皮素 氧化修饰低密度脂蛋白 维奥欣 |
| 修稿时间： | 1999年12月16 |
Effect of Wei-Ao-Xin Tablet on Plasma Endothelins and Oxide Low Density Lipoprotein in Coronary Heart Disease Cases |
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| Abstract: | Objective:To observe the effects of Wei- Ao- Xin tablet on Plasm a Endothelins(ET) and Oxide low density lipoprotein(ox L DL) in coronary heart disease cases.Methods:5 7coronary heart disease cases were divided at rnadom into two groups:Wei- Ao- Xin group treated with isosorbide dinitrate and Wei- Ao- Xin,isosorbide dinitrate group treated with isosorbide dinitrate only.Before and after the treatm ent,ET and ox L DL was m easured in venous blood.Results:The level of ET and ox L DL in coronary heart disease cases of two groups is Significantly higher than norm al people before the treatment.The decrease of ET and ox L DL in Wei- Ao- Xin group was significant(P<0 .0 1) while in the isosorbide dinitrate group(P<0 .0 5 ) .Conclusion:Wei- Ao- Xin tablet was effective in anti- myocardial ischem ia.The m echanism was adjusting the m etabloism of ET and ox L DL and im proving the endothelial cell function. |
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| Keywords: | Endothilis Oxide low density lipoprotein Coronary heart disease Wei- Ao- Xin |
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