通心络胶囊治疗糖尿病肾病疗效观察

目的探讨通心络胶囊对糖尿病肾病的临床疗效。方法将2010年5月—2012年5月55例糖尿病肾病患者随机分为两组,治疗组30例,采用通心络胶囊合并基础治疗加减;对照组25例,给予替米沙坦。疗程均为3个月。3个月后检测尿微量白蛋白,空腹血糖及糖化血红蛋白,观察症状改变及药物不良反应。结果尿微量白蛋白改善方面试验组,总有效率80.0%。对照组总有效率64.0%。两组总有效率比较,差异有显著性意义（P〈0.05）,试验组疗效优于对照组。两组患者治疗后血糖及糖化血红蛋白均较治疗前有所改善,但无统计学意义（P〉0.05）。结论通心络胶囊可以有效降低糖尿病肾病患者尿微量白蛋白,降低空腹血糖及糖化血红蛋白,表明通心络有改善患者肾功能的作用,同时具有调节患者血糖水平的作用,且无明显毒副作用。

Observation on the Clinical Curative Effect of Tongxinluo Capsule in the Treatment of Diabetic Nephropathy

Objective To explore the clinical curative effect of tongxinluo capsule on diabetic nephropathy. Methods 55 cases with diabetic nephropathy admitted from May 2010 to May 2012 were randomly divided into two groups, 30 cases in the treatment group were treated with tongxinluo capsule combined with modified cornerstone treatment, and 25 cases in the control group were treated with telmisartan. The course of treatment of both groups was 3 months. 3 months after the treatment, mieroalbuminuria, fasting blood glucose and glycosylated hemoglobin of the patients were detected, and the changes of symptoms and drug adverse reactions were observed. Results In the aspect of improving the microalbuminuria, the total effective rate of the test group was 80.0%, while that of the control group was 64.0%, the difference in total effective rate between the two groups was statistically sig- nificant （/）〈0.05）, the efficacy of the test group was better than that of the control group. After treatment, the blood glucose and glycosylated hemoglobin of both groups improved compared with those before treatment but with no statistical significance（P〉0.05）. Conclusion Tongxinluo capsule can effectively reduce the microalbuminuria and fasting blood glucose and glycosylated hemoglobin of patients with diabetic nephropathy, which shows that tongxinluo capsule can improve the renal function as well as regulate the blood sugar level of the patients without obvious side effects.