良性胃黏膜病变中Hp感染与Livin、Ki-67表达关系的研究

目的：观察Livin和Ki-67在Hp（＋/-）良性胃黏膜病变组织中的表达。方法：所有胃黏膜病变组织均来自内镜活检及手术切除标本，良性胃黏膜病变组织标本144例。采用免疫组化法测定上述胃黏膜病变组织及胃癌组织中Livin、Ki-67的表达，用甲苯胺蓝染色检测Hp。结果：Livin、Ki-67在Hp根治前后从慢性浅表性胃炎、慢性萎缩性胃炎、伴肠化、不典型增生组织中的表达率呈递增趋势，其中在慢性萎缩性胃炎和萎缩伴肠化的阳性表达率有统计学意义（ P〈0.05）。结论：在癌前病变阶段根除Hp可使部分萎缩和肠化减轻，能有效治疗Hp相关性胃炎，也可预防Hp相关性胃癌的发生。

Relation of Hp and Livin,Ki-67 protein expression in benign gastric mucosal lesions

Objective：Expression of Livin and Ki-67 was observed in the Hp（ ＋/ -）benign gastric mucosal lesions. Methods：Gastric mucosal lesions were all endoscopic and surgical biopsy specimens of benign specimens of 144 cases of gastric mucosal lesions. The gastric mucosal lesions and gastric carcinoma Livin,Ki-67 expression was determined by immunohistochemistry. Results：Livin,Ki-67 in the Hp before and after cure from chronic superficial gastritis,chronic atrophic gastritis with intestinal metaplasia,dysplasia tissues showed an increasing trend in which rates of chronic atrophic gastritis and atrophy with intestinal metaplasia positive rate was statistically significant（ P〈0. 05）. Conclusion：Hp eradication in the precancerous stage of atrophy and intestinal metaplasia is effective in trea-ting Hp-related gastritis,and prevent the occurrence of Hp-related gastric cancer.