血清和胸水中肿瘤标志物对肺癌恶性胸水诊断意义的比较

目的:探讨恶性胸腔积液患者血清和胸水中癌胚抗原（CEA）、癌抗原-125（CA-125）、铁蛋白（Ferritin）及神经元特异性烯醇化酶（NSE）对恶性胸腔积液诊断的临床意义。方法:恶性胸水的肺癌患者共37例，测量其血清和胸水中的CEA、CA-125、铁蛋白、NSE含量，并进行比较。结果:肺癌患者胸水中CEA、CA-125、铁蛋白含量均明显高于血清组（均P<0．05），而胸水和血清中NSE比较差异无统计学意义（P>0．05）。结论:肺癌患者胸水中肿瘤标志物的阳性率要高于血清中。联合检测胸水中肿瘤标志物对于肺癌的诊断意义更大。

Comparison of serum and pleural fluid tumor markers in the diagnosis of malignant pleu-ral effusion of lung cancer

Objective：To explore the significance of CEA,CA-125,Ferritin,NSE in serum and hydrothorax of patients with malignant hydrothorax caused by lung cancer. Methods：Measured and compared CEA,CA-125,Fer-ritin,NSE in serum and hydrothorax in 37 patients with malignant hydrothorax caused by lung cancer. Results：In lung cancer group tumor markers in hydrothorax were obviously higher than those in serum. The quantities of CEA,CA-125,Ferritin in hydrothorax were obviously higher than those in serum（P〈0. 005）,it was no significance for quanti-ties of NSE in hydrothorax and serum（P〉0. 05）. Conclusion：In malignant hydrothorax caused by lung cancer,the positive rate of tumor markers in hydrothorax was higher than those in serum. There was great significance in diagnosis of lung cancer by combined measuring tumor markers in hydrothorax and serum.