延长奥沙利铂输注时间预防其外周神经毒性的临床研究

目的:在胃肠道肿瘤患者应用奥沙利铂+亚叶酸钙+氟尿嘧啶(FOLFOX方案)化疗后，观察延长奥沙利铂输注时间对其外周神经毒性的预防作用。方法:98例肿瘤患者随机分为三组，A组在使用奥沙利铂时将滴注时间延长至6小时；B组延长至4小时；C组奥沙利铂滴注时间为2小时。在化疗6周期及化疗12周期后分别比较三组神经毒性的总发生率及外周神经毒性级别。结果:6周期化疗后A组神经毒性的总发生率明显低于C组(P=0.0003)；B组神经毒性的总发生率亦低于C组(P=0.034)； A组神经毒性发生率低于B组(P=0.027)，均具有统计学意义。12周期化疗后A组神经毒性的总发生率明显低于C组(P=0.002)；B组神经毒性的总发生率亦低于C组(P=0.025)；而A组和B组之间比较无统计学差异(P=0.371)。结论:使用奥沙利铂时将滴注时间延长至4-6小时可以有效减少神经毒性发生。

Clinical observation of extending the infusion time when using oxaliplatin to prevent oxali-platin neurotoxicity

Objective：To evaluate the preventive effect to oxaliplatin neurotoxicity by extending the infusion time of using oxaliplatin in patients with gastrointestinal tumor after chemotherapy with FOLFOX regimen. Methods：All 98 cancer patients were randomized into three groups. Infusion time of group A was extended to 6 hours when using oxali-platin,Infusion time of group B and group C was 4 hours and 2 hours when using oxaliplatin. Then evaluated the inci-dence and level of oxaliplatin neurotoxicity after 6 cycles and 12 cycles of chemotherapy. Results：After 6 cycles of chemotherapy,the incidence of oxaliplatin neurotoxicity of group A was lower than that of group C（P=0. 0003）,the incidence of group B was lower than that of group C as well（P=0. 034）,and the incidence of group A was lower than that of group B（P=0. 027）. After 12 cycles of chemotherapy,the incidence of group A was lower than that of group C（P=0. 002）,the incidence of group B was lower than that of group C as well（P=0. 025）,and the inci-dence had no statistical singnificance between the group A and B（P=0. 371）. Conclusion：Extending the infusion time to 4-6 hours when using oxaliplatin can reduce the incidence of oxaliplatin neurotoxicity.