氨基糖甙类抗生素致聋的家族性与交叉易感性

对3个家族中氨基糖甙类抗生素中毒性耳聋患者的家族进行调查及分析，发现几种氨基糖甙类药物之间存在家族性和交叉易感性，即在有家族性耳毒性药物致聋的家族成员中，应用任何一种氨基糖甙类抗生素，都比一般人容易发生耳中毒；即使用量不大，也易引起严重后果，特别是年幼者。此种家族性与交叉易感性属常染色体显性遗传。提示临床医生用药前应仔细询问病史，特别是有母系家族耳聋史者应禁用氨基糖甙类全部抗生素，以预防子代耳聋的发生。

Cross susceptability of ototoxicity about aminoglycoside antibiotics

A familial investigation was made in three families with deafness patients caused by aminoglycoside (AMI). The results showed that there was cross susceptatility among a few AMI antibiotics. The people with familial history of deafness caused by AMI were easier to be toxic than those without familial history,even though little dose of AMI for the former,especially for chil-dren. The cross susceptebility is dominated by inheritance of matriarchal heredity and by general chromosome. The data suggest that medical history should be inquired be fore treatment with AMI,and patients with matriarchal heredity must be prohibited from using AMI.