| 粉防已碱逆转中国仓鼠卵巢上皮细胞系对阿霉素的抗性 |
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| 引用本文： | 何琪扬 姜兵. 粉防已碱逆转中国仓鼠卵巢上皮细胞系对阿霉素的抗性[J]. 中国药理学报, 1992, 13(5): 416-419 |
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| 作者姓名： | 何琪扬 姜兵 |
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| 摘 要： |
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| 关 键 词： | 粉防己碱 阿霉素 卵巢 仓鼠 |
Reversal of doxorubicin resistance by tetrandrine in Chinese hamster ovary cell line. |
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| Q Y He,B Jiang,H Q Zhang,S B Xue. Reversal of doxorubicin resistance by tetrandrine in Chinese hamster ovary cell line.[J]. Acta Pharmacologica Sinica, 1992, 13(5): 416-419 |
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| Authors: | Q Y He B Jiang H Q Zhang S B Xue |
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| Affiliation: | Department of Biology, Beijing Normal University, China. |
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| Abstract: | Tetrandrine (Tet) 0.5 microgram.ml-1 and 1 microgram.ml-1 potentiated 2.88- and 4.3-fold growth-inhibitory effects of doxorubicin (Dox) in Chinese hamster ovary cell line (CHO), respectively, while Tet 1 microgram.ml-1 and 2.5 micrograms.ml-1 potentiated 7.3- and 8.4-fold in its resistant cell line (CHO/Dox), respectively. The colony-forming efficiencies were reduced in CHO and CHO/Dox when the cells were treated with noncytotoxic doses of Tet 2.5 micrograms.ml-1 and 5 micrograms.ml-1 in combination with different concentration of Dox. Increase in accumulation of Dox in CHO/Dox cells was shown by fluorometry. The result indicated that Tet reversed the resistance to Dox in CHO/Dox cells. |
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