| 伯喹的大鼠肝微粒体和线粒体体外代谢 |
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| 引用本文： | 倪奕昌 徐月琴. 伯喹的大鼠肝微粒体和线粒体体外代谢[J]. 中国药理学报, 1992, 13(5): 431-435 |
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| 作者姓名： | 倪奕昌 徐月琴 |
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| 摘 要： |
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| 关 键 词： | 伯喹 肝微粒体 肝线粒体 大鼠 |
Rat liver microsomal and mitochondrial metabolism of primaquine in vitro. |
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| Y C Ni,Y Q Xu,M J Wang. Rat liver microsomal and mitochondrial metabolism of primaquine in vitro.[J]. Acta Pharmacologica Sinica, 1992, 13(5): 431-435 |
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| Authors: | Y C Ni Y Q Xu M J Wang |
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| Affiliation: | Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai. |
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| Abstract: | The profiles of major metabolites of primaquine (PQ) produced from liver microsomal (MC) and mitochondrial (MT) metabolism were investigated in vitro by silica gel thin layer and reverse phase high pressure liquid chromatography (HPLC). The results indicated that 5-hydroxy primaquine (5-OH PQ) and carboxyprimaquine (CPQ) were simultaneously produced by either microsomes or pure mitochondria preparations. However, the quantitative study showed that microsomes produced approximately 19 times more 5-OH PQ but only 1/34 of the CPQ by mitochondria. |
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