| 维拉帕米增强三尖杉酯碱在体外人早幼粒细胞白血病... |
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| 引用本文： | 王磊,张鸿卿.维拉帕米增强三尖杉酯碱在体外人早幼粒细胞白血病...[J].中国药理学报,1992,13(5):471-473. |
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| 作者姓名： | 王磊 张鸿卿 |
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| 摘 要： |
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| 关 键 词： | 三尖杉酯碱类 维拉帕米 白血病 |
Enhancement of antitumor activity of harringtonine in human leukemia-60 cells in vitro by verapamil] |
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| L Wang,H Q Zhang,R H Wang,N G He,S B Xue.Enhancement of antitumor activity of harringtonine in human leukemia-60 cells in vitro by verapamil][J].Acta Pharmacologica Sinica,1992,13(5):471-473. |
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| Authors: | L Wang H Q Zhang R H Wang N G He S B Xue |
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| Institution: | Department of Biology, Beijing Normal University, China. |
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| Abstract: | The effect of harringtonine (Har) alone and in combination with verapamil (Ver) on the proliferation of human leukemia-60 (HL-60) cells in vitro were studied. IC50 of Har alone to the cells was about 49 ng.ml-1 which was reduced to its 1/3.3 and 1/4.5 when used with Ver 1 and 2 micrograms.ml-1, respectively. In colony forming test, the survival fraction of the HL-60 cells treated with Har 15 and 30 ng.ml-1 plus Ver 2 micrograms.ml-1 was reduced to 1/3.3 and 1/8 of the cells as when treated with Har alone, respectively. The results suggested that Ver enhanced the antitumor activity of Har in vitro and may used as an enhancer of Har in vivo. |
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